Table 4.
Significantly correlated NRTI-associated TDF-regimen associated mutations (TRAMs) pairs.
| Mut1 | Mut2 | Mut1% | Mut2% | Phi | Mut1 + Mut2 | Mut1 alone | Mut2 alone | Neither | Adjusted p |
|---|---|---|---|---|---|---|---|---|---|
| K70E | L228R | 6.6 | 5.5 | 0.38 | 72 | 86 | 119 | 2596 | 0 |
| A62V | K65R | 10.4 | 39.5 | 0.35 | 268 | 866 | 30 | 1709 | 0 |
| K65R | S68N | 39.5 | 8.1 | 0.35 | 225 | 8 | 909 | 1731 | 0 |
| K65R | S68G | 39.5 | 13.3 | 0.32 | 301 | 80 | 833 | 1659 | 0 |
| K65R | Y115F | 39.5 | 11.9 | 0.31 | 277 | 66 | 857 | 1673 | 0 |
| K70T | S68G | 2.6 | 13.3 | 0.29 | 56 | 325 | 20 | 2472 | 0 |
| M184V | K65R | 48.7 | 39.5 | 0.27 | 740 | 394 | 660 | 1079 | 0 |
| A62V | S68N | 10.4 | 8.1 | 0.25 | 84 | 149 | 214 | 2426 | 0 |
| K70E | D67G | 6.7 | 2.5 | 0.25 | 32 | 39 | 159 | 2642 | 0 |
| M184V | K70E | 48.7 | 6.6 | 0.24 | 178 | 13 | 1222 | 1460 | 0 |
| M184V | L74I | 48.7 | 5.7 | 0.24 | 159 | 6 | 1241 | 1467 | 0 |
| M184V | A62V | 48.7 | 10.4 | 0.22 | 243 | 55 | 1157 | 1418 | 0 |
| M184V | S68N | 48.7 | 8.1 | 0.2 | 193 | 40 | 1207 | 1433 | 0 |
| M184V | Y115F | 48.7 | 11.9 | 0.2 | 258 | 85 | 1142 | 1388 | 0 |
| K65R | K70T | 39.5 | 2.6 | 0.19 | 73 | 3 | 1061 | 1736 | 0 |
| S68G | T69I | 13.3 | 0.6 | 0.19 | 17 | 1 | 364 | 2489 | 0 |
| K70T | S68N | 2.6 | 8.1 | 0.16 | 26 | 207 | 50 | 2590 | 0 |
| L74V | Y115F | 2.6 | 11.9 | 0.15 | 32 | 311 | 44 | 2486 | 2.9E-12 |
| M184V | L228R | 48.7 | 5.5 | 0.15 | 127 | 31 | 1273 | 1442 | 2.9E-12 |
| K65R | S68D | 39.5 | 1.3 | 0.13 | 35 | 2 | 1099 | 1737 | 1.0E-08 |
| K70E | K219R | 6.6 | 1.5 | 0.13 | 14 | 30 | 177 | 2652 | 1.0E-08 |
| K70T | Y115F | 2.6 | 11.9 | 0.12 | 27 | 316 | 49 | 2481 | 4.1E-07 |
| L74I | Y115F | 5.7 | 11.9 | 0.12 | 45 | 298 | 120 | 2410 | 4.1E-07 |
| Y115F | S68N | 11.9 | 8.1 | 0.12 | 59 | 174 | 284 | 2356 | 4.1E-07 |
| M184I | K65R | 9.4 | 39.5 | 0.12 | 157 | 977 | 112 | 1627 | 4.1E-07 |
| M184V | K70Q | 48.7 | 1.6 | 0.11 | 41 | 4 | 1359 | 1469 | 1.2E-05 |
| A62V | V75I | 10.4 | 1.5 | 0.1 | 15 | 29 | 283 | 2546 | 2.7E-04 |
| K70Q | L74I | 1.6 | 5.7 | 0.1 | 11 | 154 | 34 | 2674 | 2.7E-04 |
| M184V | L74V | 48.7 | 2.6 | 0.1 | 60 | 16 | 1340 | 1457 | 2.7E-04 |
| K65R | T69del | 39.5 | 0.6 | 0.1 | 17 | 0 | 1116 | 1738 | 2.7E-04 |
| A62V | L228Q | 10.4 | 1.0 | 0.09 | 11 | 19 | 287 | 2556 | 4.5E-03 |
| K65R | V75M | 39.5 | 2.0 | 0.09 | 40 | 18 | 1094 | 1721 | 4.5E-03 |
| V75I | Y115F | 1.5 | 11.9 | 0.09 | 15 | 328 | 29 | 2501 | 4.5E-03 |
| M184V | K70T | 48.7 | 2.6 | 0.09 | 57 | 19 | 1343 | 1454 | 4.5E-03 |
| K219R | L228R | 1.5 | 5.5 | 0.09 | 10 | 148 | 34 | 2681 | 4.5E-03 |
Pairs of NRTI TRAMs co-occurring in ten or more sequences with a significant Phi correlation coefficient are listed in the order of their p values (an adjusted p < 0.05 by Holm's method). Mut1 + Mut2 contains number of sequences containing Mut1 and Mut2. Mut1 Alone contains number of sequences containing Mut1 but not Mut2. Mut2 Alone contains number of sequences containing Mut2 but not Mut1. Neither contains number of sequences containing neither of Mut1 or Mut2.
Abbreviation: TDF – tenofovir disoproxil fumarate; NRTI - nucleos(t)ide reverse transcriptase inhibitor.