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. 2017 Mar 14;18:179–187. doi: 10.1016/j.ebiom.2017.03.021

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© 2017 The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — Piperine attenuated cardiac fibrosis induced by aortic banding (AB) or repeated isoprenaline (ISO) injection. (a) Characteristic images of PSR staining and α-smooth muscle actin (α-SMA) immunostaining. (b) Comparison of the average collagen volume (n = 6). (c) Statistical results of α-SMA immunostaining (n = 6). (d) The mRNA levels of fibrosis-related genes (n = 6). (e–f) PSR staining and the average collagen volume in mice subjected to ISO injection (n = 6). (g) The mRNA levels of fibrosis-related genes (n = 6). (h) Statistical results of the heart weight (HW)/tibia length (TL) (n = 9–10). (i) Results for cross-sectional area (n = 6). Values represent the mean ± SEM. ^⁎P < 0.05 versus Sham + vehicle, ^#P < 0.05 versus AB + vehicle.