Table 2.
Correlate | N (case, control) | OR | 95% CI | p-Value | aORb | 95% CI | p-Value |
---|---|---|---|---|---|---|---|
Plasma neutralization breadth | 13, 39 | 1.00 | 0.52–1.93 | 1.00 | 1.35 | 0.73–2.53 | 0.33 |
Plasma neutralization potency | 13, 39 | 0.93 | 0.75–1.15 | 0.51 | 0.99 | 0.74–1.32 | 0.94 |
Plasma ADCC activity | 20, 60 | 0.44 | 0.06–3.10 | 0.41 | 0.74 | 0.09–6.00 | 0.78 |
Cervical ADCC activity | 17, 51 | 1.16 | 0.51–2.63 | 0.73 | 0.18 | 0.52–2.67 | 0.70 |
Plasma V1V2 IgG bindinga | |||||||
ZM109 | 20, 60 | 1.00 | 0.31–3.18 | 1.00 | 0.96 | 0.30–3.04 | 0.94 |
ZM53 | 20, 60 | 0.89 | 0.24–3.33 | 0.89 | 0.97 | 0.26–3.63 | 0.96 |
Case A2 | 20, 60 | 1.00 | 0.27–3.69 | 1.00 | 1.05 | 0.27–4.08 | 0.94 |
Average | 20, 60 | 0.79 | 0.48–1.29 | 0.34 | 0.64 | 0.20–2.06 | 0.46 |
Plasma gp140 IgA binding | 20, 60 | 0.93 | 0.58–1.49 | 0.78 | 0.85 | 0.51–1.41 | 0.52 |
ADCC = antibody-dependent cell-mediated cytotoxicity, aOR = adjusted odds ratio, CI = confidence interval, OR = odds ratio, SI = superinfection, VL = viral load.
Dichotomized detectable vs. undetectable.
Adjusted for VL.