Fig. 4.

Mean and CpG site-specific methylation results reported for exon 1F and its promoter in NR3C1. First exon variants in red represent the proximal promoter region. ▼ or ▲ denote hypomethylation or hypermethylation, respectively. ↓ or ↑ arrows denote a correlation between observed methylation at a specific CpG site and decreased or increased NR3C1 expression levels, respectively. “Null” denotes no methylation found, or no difference found in methylation between healthy controls and those with the disease under investigation. Boxes around CpG site numbers represent NGFI-A transcription factor binding sites according to McGowan et al. (2009). CpG numbering taken from Palma-Gudiel et al. (2015). Figure is not to scale.