Figure 1. Striatal [¹¹C]raclopride nondisplaceable binding potential (BP_ND) scatterplots for the early (30–40 minutes) and late phase (60–90 minutes) analyses.

Upper images: During early phase analyses, a paired t test between ictal and interictal migraine phases showed higher [¹¹C]raclopride BP_ND during the ictal phase compared to the interictal phase both on voxel (A) and cluster (B) levels. Lower images: During late phase analyses, a higher [¹¹C]raclopride BP_ND was also observed during the ictal compared to the interictal phase with sustained thermal pain threshold (sustained thermal pain threshold challenge) and with ictal spontaneous migraine and allodynia, both on voxel (C) and cluster (D) levels.