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. 1990 Jun;87(11):4222–4225. doi: 10.1073/pnas.87.11.4222

Protection of mice against tumor growth by immunization with an oncogene-encoded growth factor.

D Talarico 1, M Ittmann 1, A Balsari 1, P Delli-Bovi 1, R S Basch 1, C Basilico 1
PMCID: PMC54080  PMID: 2190216

Abstract

The K-fgf/hst oncogene encodes a growth factor of the fibroblast growth factor (FGF) family that is secreted and transforms cells through a mechanism of autocrine cell proliferation. K-fgf-transformed cells are highly tumorigenic in immunocompetent allogeneic and syngeneic animals. BALB/c mice were immunized with a bacterial fusion protein consisting of a portion of the MS2 polymerase and of the human K-FGF precursor lacking only the first 4 amino acids or with a recombinant protein corresponding to the mature, secreted form of K-FGF (176 amino acids). They were then challenged with syngeneic K-fgf- or H-ras-transformed cells. Vaccinated animals exhibited a significant degree of protection against tumor induction, which was specific for K-fgf-transformed cells and correlated with the ability of the immunized mice to produce high titers of anti-K-FGF antibodies. Thus immunization with a single oncogene product can protect animals against tumor cells expressing this oncogene.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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