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. 1990 Jun;87(11):4345–4348. doi: 10.1073/pnas.87.11.4345

Neuronal modulation of calcium channel activity in cultured rat astrocytes.

V Corvalan 1, R Cole 1, J de Vellis 1, S Hagiwara 1
PMCID: PMC54106  PMID: 2161537

Abstract

The patch-clamp technique was used to study whether cocultivation of neurons and astrocytes modulates the expression of calcium channel activity in astrocytes. Whole-cell patch-clamp recordings from rat brain astrocytes cocultured with rat embryonic neurons revealed two types of voltage-dependent inward currents carried by Ca2+ and blocked by either Cd2+ or Co2+ that otherwise were not detected in purified astrocytes. This expression of calcium channel activity in astrocytes was neuron dependent and was not observed when astrocytes were cocultured with purified oligodendrocytes.

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Selected References

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