Table 3.
(Chiral) additive screening in the [Co(MeTAA)]‐catalysed cyclopropanation of methylacrylate and styrene.[a]
| Entry | R | Additive | T [°C] | t [h] | Yield [%][b] | trans/cis [c] |
|---|---|---|---|---|---|---|
| 1 | COOMe | – | 20 | 1 | 78 | 97:3 |
| 2 | COOMe |
|
20 | 1 | 99 | 94:6 |
| 3 | COOMe |
|
20 | 1 | 81 | 95:5 |
| 4 | COOMe |
|
20 | 1 | 99 | 96:4 |
| 5 | COOMe |
|
20 | 1 | 82 | 98:2 |
| 6 | COOMe |
|
0 | 2 | 83 | 97:3 |
| 7 | COOMe |
|
−78 | 5 | 65 | 99:1 |
| 8 | Ph | – | 20 | 1 | 85 | 85:15 |
| 9 | Ph |
|
0 | 2 | 92 | 87:13 |
| 10 | Ph |
|
−78 | 5 | 98 | 89:11 |
| 11 | Ph |
|
−78 | 5 | 93 | 89:11 |
[a] Performed using 1.5 mol % [Co(MeTAA)] and 25 mol % additive with 1.0 equiv. of EDA (0.38 m) and 3 equiv. of olefin. [b] Isolated yields. [c] Determined by using GC.