In the article “Orphan receptor small heterodimer partner is an important mediator of glucose homeostasis” (Wang L, Huang J, Saha P, Kulkarni RN, Hu M, Kim YD, Park KG, Chan L, Rajan AS, Lee I, Moore DD Molecular Endocrinology 2006; 20(11):2671–2681) we have found that Figure 2A, as presented, contains data that are irreproducible. The authors regret the inclusion of this figure and wish to retract the paper.