Table 5. Multivariable robust Cox model result on progression to advanced AMD.
| AREDS | AREDS2 | Test for differencea | |||
|---|---|---|---|---|---|
| HR (95% CI) | P Value | HR (95% CI) | P Value | P Value | |
| Variable | |||||
| Age (yr) | 1.05 (1.03, 1.06) | 6.4 × 10−10 | 1.06 (1.05, 1.07) | 2.8 × 10−28 | 0.14 |
| Smoking | |||||
| Never | Reference | Reference | |||
| Former | 1.14 (0.98, 1.33) | 0.06 | 1.18 (1.02, 1.37) | 0.03 | 0.75 |
| Current | 1.98 (1.51, 2.58) | 5.7 × 10−7 | 1.30 (0.92, 1.81) | 0.13 | 0.05 |
| Education | |||||
| ≤High school | Reference | Reference | |||
| >High school | 0.87 (0.75, 1.01) | 0.06 | 0.92 (0.78, 1.07) | 0.27 | 0.65 |
| Baseline study eye AMD severity score | 1.85 (1.78, 1.92) | 4.3 × 10−226 | 1.90 (1.74, 2.07) | 8.7 × 10−48 | 0.61 |
| GRSb | 1.34 (1.26, 1.42) | 1.6 × 10−22 | 1.11 (1.05, 1.18) | 2.1 × 10−4 | 1.0 × 10−5 |
a
For each model coefficient estimate [i.e., log(HR)], a Wald test was performed to test whether the coefficient estimates differ between AREDS and AREDS2.
b
For 0.1 unit increase in GRS.