Table 2. MLEs of various DFEs.
| Data set | DFE | Parameter MLEs | Log-likelihood | AIC | |ΔAIC|a |
|---|---|---|---|---|---|
| LuCamp | Gamma | α = 0.215, β = 562.1 | −3334.7 | 6673.4 | 13 |
| Neu+gamma | pneu = 0.164, α = 0.338, β = 367.7 | −3327.2 | 6660.4 | 0 | |
| Neu+exp+let | pneu = 0.304, pexp = 0.613, λ = 66.56 | −3337.8 | 6681.6 | 21.2 | |
| Discreteb | p1 = 0.309, p2 = 0.024, p3 = 0.247, p4 = 0.372 | −3334.1 | 6676.2 | 15.8 | |
| 1kG EUR | Gamma | α = 0.186, β = 875.0 | −1450.5 | 2905.0 | 0 |
| Neu+gamma | pneu = 0.031, α = 0.199, β = 820.6 | −1450.8 | 2907.6 | 2.6 | |
| Neu+exp+let | pneu = 0.312, pexp = 0.509, λ = 41.48 | −1472.0 | 2950.0 | 45 | |
| Discreteb | p1 = 0.286, p2 = 0.099, p3 = 0.222, p4 = 0.305 | −1453.4 | 2914.8 | 9.8 | |
| ESP EUR | Gamma | α = 0.169, β = 1327.4 | −3012.6 | 6029.2 | 2.6 |
| Neu+gamma | pneu = 0.092, α = 0.207, β = 1082.3 | −3010.3 | 6026.6 | 0 | |
| Neu+exp+let | pneu = 0.341, pexp = 0.504, λ = 63.90 | −3071.6 | 6149.2 | 122.6 | |
| Discreteb | p1 = 0.334, p2 = 0.041, p3 = 0.201, p4 = 0.306 | −3029.5 | 6067.0 | 40.4 |
These results are reported assuming LNS/LS = 2.31 and μ = 1.5×10−8. See Table S4 in File S1 for additional information. The shape and scale parameters of the gamma distribution are denoted with α and β, respectively, and the rate parameter of the exponential distribution is denoted with λ. Neu, neutral; exp, exponential; let, lethal; 1kG, 1000 Genomes.
a
Change in AIC relative to the model with the lowest AIC.
b
In terms of |s|, these parameters correspond to the ranges of |s| corresponding to: [0, 10−5), [10−5, 10−4), [10−4, 10−3), and [10−3, 10−2), respectively. The mass in the [10−2, 1] range is the complement of the total mass of the four aforementioned categories.