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. 1976 Feb;57(2):245–248. doi: 10.1104/pp.57.2.245

Inhibition of ent-Kaurene Oxidation and Growth by α-Cyclopropyl-α-(p-methoxyphenyl)-5-pyrimidine Methyl Alcohol 1

Ronald C Coolbaugh a,2, Roxanne Hamilton a
PMCID: PMC542001  PMID: 16659460

Abstract

Growth of Alaska peas (Pisum sativum) is inhibited more than 60% by α-cyclopropyl-α-(p-methoxyphenyl)-5-pyrimidine methyl alcohol (ancymidol) treatment. This growth inhibition can be reversed completely by gibberellic acid application. Cell-free enzyme preparations from pea shoot tips and wild cucumber (Marah oreganus) endosperm were used to test the effects of this substituted pyrimidine on the incorporation of mevalonic acid-14C into ent-kaurene and ent-kaurenol, respectively. Ancyidol (10−6m) completely blocks the conversion of ent-kaurene to ent-kaurenol. This result was confirmed with the wild cucumber endosperm system by testing the direct conversion of labeled ent-kaurene to ent-kaurenol. Ancymidol at higher concentrations (10−3m) inhibits the incorporation of mevalonic acid-14C into ent-kaurene to a lesser extent. It is concluded that one mode of action of this growth regulator is the inhibition of gibberellin biosynthesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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