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. 2017 May 5;5:51. doi: 10.1186/s40168-017-0265-7

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Analysis of samples collected ON (n = 29) vs OFF (n = 132) systemic antibacterial therapies. a Significant differences were found in Shannon alpha diversity measures as measured by a paired t test. b Bray-Curtis PCoA plot of samples ON vs OFF systemic therapies. PERMANOVA reveals significant community-wide differences (p = 0.02*), as shown in the PCoA plot. Even when permutations are constrained by patient significance is observed (p = 0.04). c Significant differences in the log abundance of samples ON vs OFF systemic therapies were detected in Streptococcus (OTU2) using a paired t test