Table 1.
Patient characteristics for cohort (n =24) being studied. Values were taken at the initiation of AZLI
| Characteristics of patient cohort | Responders (n = 14) | IQR | Non-responders (n = 10) | IQR | p value |
|---|---|---|---|---|---|
| Female sex | 9 | 3 | 0.24 | ||
| Median age, years | 41.0 | 35.0–46.0 | 40.0 | 32.0–44.0 | 0.4 |
| Median age at diagnosis, years | 2.8 | 1.9–11.5 | 0.3 | 0.1–0.5 | 0.04 |
| BMI (Kg/m2) | 21.6 | 20.9–22.7 | 21.9 | 18.9–24.8 | 0.8 |
| Lung disease status | |||||
| Mild FEV1 (≥70%) | 1 | 1 | |||
| Moderate FEV1 (40–70%) | 7 | 3 | |||
| Severe FEV1 (≤40%) | 6 | 6 | |||
| aMedian FEV1 (%) predicted at initiation | 46.0 | 33.0–57.0 | 38.5 | 33.0–50.0 | 0.4 |
| aMedian FEV1 (%) predicted post-initiation | 45.0 | 35.0–57.0 | 33.5 | 30.0–48.0 | 0.2 |
| Genotype | |||||
| ΔF508 homozyogous | 8 | 6 | |||
| ΔF508 heterozygous | 3 | 3 | |||
| CF related co-morbidities | |||||
| Pancreatic insufficiency | 12 | 10 | |||
| CF-related diabetes | 4 | 4 | |||
| Impaired glucose tolerance | 5 | 3 | |||
| Liver disease | 1 | 1 | |||
| Bone disease | 5 | 3 | |||
| Sinus disease | 6 | 3 | |||
| Recurrent distal intestinal obstructive syndrome (DIOS) | 4 | 1 | |||
| Cultured Pathogens | |||||
| P. aeruginosa | 14 | 10 | |||
| E. coli | 1 | 0 | |||
| Methicillin susceptible S. aureus | 0 | 3 | |||
| Group B streptococcus Spp. | 1 | 0 | |||
aRepresents the median of all spirometry values recorded in the year including those where a pulmonary exacerbation occurred