Skip to main content
. 2016 Dec 16;31(5):1108–1116. doi: 10.1038/leu.2016.360

Figure 3.

Figure 3

Adaptive-like NK cells in treatment discontinuation. Frozen PB MNCs from 1-month time-point were analyzed with multicolor flow cytometry. (a) Adaptive-like NK cells based on the downregulation of EAT2, SYK, FCɛR1γ and PLZF expression at 1 month. EAT-2– in non-relapsing group 2.1% (n=19), early relapsing 0.5% (n=13), late relapsing 1.1% (n=7) of lymphocytes, **P<0.01. SYK– non-relapsing 3.3%, early relapsing 1.3%, late relapsing 1.3% of lymphocytes, P=NS. FcɛRγ– non-relapsing 5.9%, early relapsing 1.5%, late relapsing 3.5% of lymphocytes, P=0.18. PLZF– non-relapsing 3.7%, early relapsing 1.4%, late relapsing 5.0% of lymphocytes, P=0.11. Box-and-whisker plots present 5–95 percentiles. (b) The proportion of EAT2- adaptive-like NK cells at 1 month plotted according to the treatment-free remission time (n=39). For non-relapsing patients, the latest follow-up time is reported. Statistical significance was analyzed with non-parametric Mann–Whitney test (a) and with Spearman correlation (b).