Figure 2. CFTRinh-172 exerted a significantly anti-proliferative, apoptotic and cell cycle-arrest effect on CFTR-high Ph+ leukemia cells but had little effect on normal cells.

(A) The inhibition of proliferation (MTT assay). (B) The induction of apoptosis (Annexin-V/PI FACS). (C) Cell cycle-arrest effect. Top: cell lines; bottom: primary leukemia cells. The data represented means ± SD of three experiments.