Table 3. Clinical features of the patients enrolled in this study.
Patient | Sex (M/F) | Age (years old) | Side of tumor | Date of surgery (year, month) | Histological diagnosis (WHO classification) | Months of survival | Preoperative KPS | Postoperative KPS | Preoperative Deficit | Postoperative Deficit (at the discarge) | Postoperative treatment | Recurrence |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | M | 77 | Right fronto-pariel | 2011, Sept. | IV grade | 6 | 70 | 70 | Moderate left hemiparesis | No further deficit than preop time | CT + RT (Stupp protocol*), Levetiracetam | After 6 months |
2 | M | 75 | Right fronto-temporal | 2013, Sept. | IV grade | 11 | 80 | 80 | Mild ideo-motor apraxia, mild left lower limb deficit with some difficulties with walking | No further deficit than preop time | CT + RT (Stupp protocol*), Levetiracetam | After 10 months |
3 | F | 72 | Right fronto-temporal | 2013, Sept. | IV grade | 11 | 80 | 90 | Mild ideo-motor slowing, mild motor deficit in left upper limb | Improvement of ideo-motor slowing and preop motor deficit | CT + RT (Stupp protocol*), Levetiracetam | No |
4 | M | 36 | Left Temporal | 2013, Sept. | III grade | Living | 100 | 100 | No deficit | No deficit | RT | No |
5 | F | 45 | Left frontal | 2013, Oct. | II grade | Living | 90 | 90 | Dysphasia | Improvement of preoperative dysphasia | RT after the first operation. CT after the second operation. Levetiracetam | After 22 month (Re-operation) |
6 | F | 48 | Left frontal | 2013, Dec. | II grade | Living | 90 | 100 | Dysphasia | Improvement of preoperative dysphasia | RT. Levetiracetam | No |
7 | F | 65 | Left fronto-temporal | 2013, Nov. | IV grade | 17 | 80 | 80 | Right hemiparesis (Moderate in upper limb, mild in lower limb) | No further deficit than preop time | CT+ RT (Stupp protocol*). Levetiracetam | After 13 months |
8 | F | 37 | Right temporal | 2014, Nov. | IV grade | Living | 90 | 90 | No deficit | No deficit | CT+ RT (Stupp protocol*). Levetiracetam | No |
9 | F | 68 | Left Temporo-parietal | 2015, Oct. | IV grade | 14 | 90 | 90 | Mild ideo-motor slowing, very mild right upper limb deficit | No further deficit than preop time | RT + CT (Stupp protocol*). Levetiracetam | After 10 months |
10 | F | 27 | Left temporal | 2016, Feb. | II grade | Living | 100 | 100 | Dysphasia | No deficit | RT + CT (Stupp protocol*). Levetiracetam | No |
*Stupp protocol: Adjuvant treatment with radiotherapy (RT) and chemotherapy (CT). Focal radiotherapy was delivered once daily at 2Gy per fraction, 5 day/week, for a total of 60 Gy, as prescribed by the radiation oncologist, according to the guidelines of the International Commission on Radiological Units. Concomitant treatment with temozolomide was prescribed by the oncologist at a dose of 75 mg/m2 for each day of radiation treatment. Four weeks after radiotherapy, patients received adjuvant temozolomide chemotherapy, 150 to 200 mg/m2 on days 1 to 5 at 28-day intervals. All patients were subjected to radical exeresis, except patient #10 subjected to a subtotal exeresis.