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. 2014 Feb 24;3(2):e89. doi: 10.1038/oncsis.2014.2

Figure 5.

Figure 5

Suppression of AKT phosphorylation and induction of LC3 by TNIK inhibitor or siRNA-mediated TNIK knockdown. (a) PAMC82 and AZ521 cells were treated with TNIK inhibitor at the indicated concentrations for 2 h, and cell lysates were collected for western blotting analysis with the indicated antibodies. (b) PAMC82 and AZ521 cells were transfected with siRNA against TNIK or scrambled, and cell lysates were collected for western blotting analysis with the indicated antibodies. The data presented here are representative from three independent experiments. UN, untreated cells, NC, scrambled control, S2, TNIKsiRNA 2, S3, TNIKsiRNA3.