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. 2017 May 10;69(6):1207–1216. doi: 10.1161/HYPERTENSIONAHA.117.09156

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© 2017 The Authors.

Hypertension is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 4. — NPNT (nephronectin) is a Wnt target gene and produces aldosterone via Wnt. A, Constitutive Wnt activation (ΔN-Bcat) induces NPNT mRNA expression, whereas constitutive Wnt repression (ΔN-TCF4) decreased NPNT expression compared with vector control (n=3). B, Wnt transcriptional complex T-cell factor/lymphoid enhancer factor (TCF/LEF) activity decreased in NPNT-overexpressed and increased in NPNT-silenced samples, as measured by firefly/renilla luciferase assay (n=6; n=4). C, Wnt inhibitor LGK-974 attenuated the increase in protein-normalized aldosterone production with addition of NPNT protein, compared with negative controls BSA and fibronectin (n=3). Bars represent mean expression per group±SEM. Statistical analyses were conducted by Student t test. *P<0.05; **P<0.005; ***P<0.0005.