Table 1.
Associations between serum sCD23, sCD27, sCD30, and sTNFR2 and future NHL risk (overall and by follow-up period) in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study
| Analyte, Units | Categorya | Stratified by Follow-up Time From Phlebotomy To Case Diagnosis | |||||||
|---|---|---|---|---|---|---|---|---|---|
|
|
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| All Cases and Controls | 2–<8 Years | 8–<15 Years | 15–23 Years | ||||||
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|
|
|
|
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| (272 Cases, 325 Controls) | (85 Cases, 105 Controls) | (101 Cases, 118 Controls) | (86 Cases, 102 Controls) | ||||||
| NCab/NCont | ORc (95% CI) | NCa/NCont | OR (95% CI) | NCa/NCont | OR (95% CI) | NCa/NCont | OR (95% CI) | ||
| sCD23d, U/ml | ≤ 3.125 | 87/139 | 1.0 | 24/35 | 1.0 | 35/48 | 1.0 | 28/56 | 1.0 |
| 3.126 – 53.561 | 65/68 | 1.5 (0.9–2.3) | 20/21 | 1.8 (0.8–4.3) | 26/26 | 1.3 (0.6–2.7) | 19/21 | 1.7 (0.7–4.0) | |
| > 53.561 | 84/69 | 2.4 (1.5–3.8) | 28/27 | 2.1 (0.9–5.1) | 28/27 | 1.5 (0.7–3.2) | 28/15 | 5.1 (1.8–14.6) | |
| Ptrend = 0.0005 | Ptrend = 0.12 | Ptrend = 0.30 | Ptrend = 0.002 | ||||||
| sCD27, U/ml | ≤ 44 | 56/111 | 1.0 | 10/31 | 1.0 | 24/44 | 1.0 | 22/36 | 1.0 |
| 45 – 61 | 94/112 | 2.0 (1.2–3.1) | 23/37 | 3.9 (1.2–12.4) | 27/33 | 1.3 (0.6–2.9) | 44/42 | 2.0 (0.9–4.1) | |
| > 61 | 121/102 | 3.0 (1.8–4.9) | 52/37 | 8.4 (2.6–27.8) | 50/41 | 2.7 (1.3–5.7) | 19/24 | 1.4 (0.6–3.5) | |
| Ptrend < 0.0001 | Ptrend = 0.0005 | Ptrend = 0.007 | Ptrend = 0.46 | ||||||
| sCD30, pg/ml | ≤ 19 295 | 52/107 | 1.0 | 13/29 | 1.0 | 20/36 | 1.0 | 19/42 | 1.0 |
| 19 296 – 29 775 | 105/111 | 2.5 (1.5–4.2) | 31/33 | 3.5 (1.3–9.5) | 38/43 | 2.1 (0.9–4.7) | 36/35 | 2.5 (1.1–5.7) | |
| > 29 775 | 114/106 | 3.3 (1.9–5.5) | 41/43 | 4.1 (1.4–11.8) | 43/38 | 2.6 (1.1–6.1) | 30/25 | 3.7 (1.5–9.3) | |
| Ptrend < 0.0001 | Ptrend = 0.03 | Ptrend = 0.04 | Ptrend = 0.01 | ||||||
| sTNFR2, pg/ml | ≤ 5 634.40 | 67/108 | 1.0 | 11/28 | 1.0 | 24/36 | 1.0 | 32/44 | 1.0 |
| 5 634.41 – 7 841.82 | 93/110 | 1.6 (1.0–2.6) | 31/32 | 3.2 (1.2–8.4) | 36/42 | 1.3 (0.6–2.8) | 26/36 | 1.1 (0.4–2.5) | |
| > 7 841.82 | 111/107 | 2.0 (1.2–3.3) | 43/45 | 3.6 (1.2–10.4) | 41/40 | 1.8 (0.8–4.1) | 27/22 | 1.5 (0.6–3.4) | |
| Ptrend = 0.008 | Ptrend = 0.04 | Ptrend = 0.13 | Ptrend = 0.33 | ||||||
NHL indicates non-Hodgkin lymphoma; NCa, number of cases; NCont, number of controls; OR, odds ratio; CI, confidence interval.
a
sCD23 categorized as ≤ assay limit of detection, ≤ the median among controls, and > control median. Other analytes categorized using tertiles among controls as cutpoints.
b
Case frequencies do not include one case without assay data for the four analytes shown in this table.
c
ORs computed by conditional logistic regression with adjustment for cigarette pack-years.
d
sCD23 analyses restricted to samples in batches 3 onward.