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. 1976 Oct;58(4):592–594. doi: 10.1104/pp.58.4.592

Effects of Chloramphenicol on the Circadian Rhythm of Neurospora crassa1

John G Frelinger a,2, Harvey Motulsky a,3, Dow O Woodward a
PMCID: PMC543288  PMID: 16659724

Abstract

Chloramphenicol, an inhibitor of mitochondrial protein synthesis, shortened the period length of the circadian rhythm in the Timex strain of Neurospora crassa by 2 hours. Both the l(+) threo and d(−) threo optical isomers had the same effect on the period of the rhythm, whereas only the d(−) threo isomer significantly inhibited mitochondrial protein synthesis. Tetracycline, another inhibitor of mitochondrial protein synthesis, did not change the period of the circadian rhythm. The effect of chloramphenicol on the circadian rhythm is, therefore, presumably not directly related to inhibition of mitochondrial protein synthesis, suggesting that chloramphenicol has other effects.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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