Figure 2. Parameters of activities in the open field test.

Total distances moved in the open field were measured. Vertical numbers during the experiment and numbers of entries into the center of the open field were counted. Time spent in the center of the open field was calculated. *P < 0.05, **P < 0.01, ***P < 0.001, PSD, PDZ vs. Con. Con: control ZDF rats; PSD: ZDF rats treated with PS; PDZ: ZDF rats treated with PS combining ZBPYR administration.