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. 2017 Feb 23;8(17):28683–28695. doi: 10.18632/oncotarget.15640

Figure 5. miR-146b-5p exerts its functions through inhibiting the TRAF6/p-Akt signaling pathway.

Figure 5

In MHCC97-H cells with miR-146b-5p over-expression, the phosphorylation of Akt (p-Akt) was impaired and the expression levels of Bcl-2, Mcl-1 and MMP-9 were decreased. In Hep3B cells with miR-146b-5p knockdown, enhanced the phosphorylated Akt induced the expression of Bcl-2, Mcl-1 and MMP-9. Neither over-expression nor knockdown of miR-146b-5p could find any significant changes of total Akt (t-Akt) expression. *P<0.05. Immunoblotting was performed at least in triplicate and the data are presented as the (mean ± SD).