Table 1. Comparisons on values of heart function before and after animal model establishment.
| Control group | Adriamycin group |
BMSCs group | NC group | miR-21 overexpression group |
||
|---|---|---|---|---|---|---|
| Before transfection | EF (%) | 84.59 ± 1.5 | 41.09 ± 2.3* | 41.29 ± 2.7* | 41.12 ± 2.78* | 42.09 ± 2.9* |
| FS (%) | 47.9 ± 2.4 | 15.78 ± 1.32* | 16.69 ± 1.3* | 16.78 ± 1.35* | 17.5 ± 1.2* | |
| LVEDD (mm) | 9.86 ± 0.05 | 4.11 ± 0.16* | 4.02 ± 0.08* | 3.99 ± 0.08* | 4.17 ± 0.2* | |
| LVESD (mm) | 10.37 ± 0.15 | 4.01 ± 0.09* | 3.99 ± 0.11* | 4.00 ± 0.08* | 4.08 ± 0.10* | |
| After transfection | EF (%) | 83.79 ± 1.66 | 40.97 ± 2.18* | 49.8 ± 3.5*#△ | 49.0 ± 3.3*#△ | 75.9 ± 1.6*#&△ |
| FS (%) | 47.8 ± 2.41 | 16.21 ± 1.24* | 24. 4 ± 1.2*#△ | 24.9 ± 1.3*#△ | 38.8 ± 2*#&△ | |
| LVEDD (mm) | 9.91 ± 0.05 | 4.15 ± 0.16* | 6.12 ± 0.13*#△ | 6.13 ± 0.19*#△ | 8.0 ± 0.1*#&△ | |
| LVESD (mm) | 10.40 ± 0.14 | 4.14 ± 0.11* | 6.12 ± 0.7*#△ | 6.10 ± 0.1*#△ | 8.01 ± 0.5*#&△ |
Note: EF, ejection fraction; FS, Fraction shortening; LVEDD, Left ventricular end-diastolic dimension; LVESD, left ventricular end systolic diameter *, P < 0.05, compared with control group;#, P < 0.05, compared with Adriamycin group; &, P < 0.05, compared with BMSCs group and NC group; △, P < 0.05, compared with before transfection; NC, negative control; BMSCs, bone marrow mesenchymal stem cells; miR-21, microRNA-21.