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. 2017 Apr 6;66(6):1560–1571. doi: 10.2337/db16-1238

Figure 1.

Figure 1

Deletion of IR in AgRP neurons impairs the ability of insulin to suppress HGP without affecting adipose tissue insulin action. A: Schematic representation of hyperinsulinemic-euglycemic clamp protocol in mice. B: Blood glucose of AgRP IR WT and AgRP IR KO mice before and during the clamp period. C: GIR required to maintain euglycemia during the hyperinsulinemic clamps. D: Mean GIR. E: Rd of glucose. F: hGP during basal and clamp periods. G: Percentage suppression of hGP. H: Ra of glycerol in plasma at basal and steady state during the clamp period. Plasma levels of insulin (I), TGs (J), glycerol (K), and NEFA (L) during basal and clamp periods. M: IL-6 mRNA expressions in liver after hyperinsulinemic clamps. n ≥6 per group. Values are mean ± SEM. *P < 0.05 compared with WT or basal value of respective group.