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. 2017 Apr 6;66(6):1560–1571. doi: 10.2337/db16-1238

Figure 4.

Figure 4

Chronic HFD feeding leads to hepatic steatosis only in POMC IR KO mice without affecting glucose tolerance. A: Body weight in mice lacking IR in AgRP or POMC neurons after 5 months of 60% HFD feeding. B: Whole-body glucose metabolism of AgRP IR KO mice and POMC IR KO mice as assessed by glucose tolerance test (intraperitoneal injection of 1.5 g/kg body wt). C: Plasma levels of TGs, glycerol, and NEFA of AgRP IR KO mice at the time of sacrifice. D: TG levels in liver of AgRP IR KO mice. E: Plasma levels of TGs, glycerol, and NEFA of POMC IR KO mice at the time of sacrifice. F: TG levels in liver of POMC IR KO mice. n ≥6 per group. Values are mean ± SEM. *P < 0.05 compared with respective WT.