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. 2017 May 30;8(3):e00778-17. doi: 10.1128/mBio.00778-17

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Copyright © 2017 Singh and Aballay.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 7 — vit-2(ac3) animals exhibit reduced expression of immune genes. (A) List of immune-related genes that are downregulated in vit-2(ac3) animals compared to SJ4005 animals. (B) qRT-PCR for selected immune genes. The bar graph shows the means plus SD for three independent experiments. Comparing the values of all genes in vit-2(ac3) animals versus SJ4005 animals, P < 0.0001. (C) Model for the effects of mutations in vitellogenin proteins on innate immunity. Mutations in vitellogenin proteins lead to enhanced ER stress. Accumulation of mutated vitellogenin proteins and/or enhanced ER stress lead to suppression of secreted immune effectors in an IRE-1-independent manner, resulting in an enhanced susceptibility to pathogen infection.