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. 2017 Jun;102(6):1054–1065. doi: 10.3324/haematol.2016.159053

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Figure 2. — Levels of ALDH1A1 are variable between acute myeloid leukemias (AMLs) and have prognostic significance. (A) Aldefluor staining was performed to analyze single cell ALDH activity in representative samples of human primary AMLs that co-expressed CD123, a useful discriminator of AML and normal hematopoietic stem cells (HSCs). (B) Summary of Aldefluor staining in 18 different AML samples. (C) Association of ALDH1A1 expression level and poor, intermediate and good risk cytogenetic categories (TCGA dataset; ****P<0.0001). (D) Event-free survival (EFS) and overall survival (OS) Kaplan-Meier curve plots showing prognostic value of ALDH1A1 expression in all AML samples analyzed in the Cancer Genome Atlas dataset.