Figure 8.

Effects of the H₁R agonist, PEA, on changes in sleep latency (a) and sleep duration (b) in ICR mice treated with DOX (30 mg/kg) and RBS (1000 mg/kg). Drugs were administered (p.o.) to mice 45 min before the injection of pentobarbital (45 mg/kg, i.p.). PEA (150 mg/kg, i.p.) was injected 10 min before the administration of test samples. Each column represents mean ± SEM (n = 10). ** p < 0.01, significant difference when compared to the CON group (Dunnett’s test). ## p < 0.01, significant difference between treatment with PEA and treatment without PEA (unpaired Student’s t-test). CON, control; DOX, doxepin hydrochloride; NS, not significant; PEA, 2-pyridylethylamine dihydrochloride; RBS, rice bran supplement.