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(a) Organ and (b) vessel compartments. Each organ is modeled with three subcompartments: Intravascular (IV), extracellular (EC), and intracellular (IC). CIV and CEC are intravascular and extracellular concentrations, and VIV and VEC are intravascular and extracellular volumes. Note that input and output blood flow rates (Q) are assumed to be equal.
