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. 1990 Sep;87(17):6477–6481. doi: 10.1073/pnas.87.17.6477

Alternative splicing produces transcripts encoding two forms of the alpha subunit of GTP-binding protein Go.

M Strathmann 1, T M Wilkie 1, M I Simon 1
PMCID: PMC54559  PMID: 1697681

Abstract

The alpha subunit of the guanine nucleotide-binding protein Go ("o" for other) is believed to mediate signal transduction between a variety of receptors and effectors. cDNA clones encoding two forms of Go alpha subunit were isolated from a mouse brain library. These two forms, which we call GoA alpha and GoB alpha, appear to be the products of alternative splicing. GoA alpha differs from GoB alpha over the C-terminal third of the deduced protein sequence. Both forms are predicted to be substrates for ADP-ribosylation by pertussis toxin. GoA alpha transcripts are present in a variety of tissues but are most abundant in brain. The GoB alpha transcript is expressed at highest levels in brain and testis. It is possible that GoA alpha and GoB alpha have different functions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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