Table 2. Baseline characteristics of immune phases of chronic hepatitis B.
| Variable | HBeAg (+) | HBeAg(-) | P | ||
|---|---|---|---|---|---|
| IT (n = 40) | IC (n = 100) | LR (n = 28) | ENH (n = 37) | ||
| Male (%) | 25(62.5) | 78 (78.0) | 19 (67.8) | 28 (75.7) | 0.554a |
| Age (years) | 32(24-39) | 38 (28-46) | 41(26-51) | 40(32-54) | <0.001b |
| HBeAg+(%) | 40 (100) | 100 (100) | 0 (0) | 0 (0) | <0.001a |
| HBVDNA+(%) | 40 (100) | 100 (100) | 7(25.0) | 35(94.6) | <0.001a |
| Log10 (HBVDNA load) | 7.70 (7.25-8.18) | 5.07 (4.75-6.73) | 0 (0-3.19) | 5.30 (4.04-6.04) | <0.001b |
| HBsAg(IU/mL) | 4489(3595-6512) | 2332(838-5407) | 1956(212-3775) | 2905(1770-4161) | <0.001b |
| ALT (U/L) | 29 (21-39) | 263 (1367-453) | 35 (24-41) | 253 (123-465) | <0.001b |
| AST (U/L) | 27 (22-33) | 117 (67-232) | 20 (18-36) | 152(98-319) | <0.001b |
| TBIL (umol/L) | 13.1 (7.4-18.6) | 49.8 (18.4-87.1) | 12.5 (9.5-17.7) | 18 (15-25) | <0.001b |
| ALB (g/L) | 43.6 (42.3-48.3) | 41.8 (39.1-44.7) | 43.2 (40.1-46.2) | 44.8 (40.8-47.9) | <0.001b |
Quantitative variables were expressed as the median (centile 25; centile 75). Categorical variables were expressed as number (%).
a, Chi-square test; b, Kruskal-Wallis test.
IT, immune tolerance phase; IC, immune clearance phase; LR, low-replicative phase; ENH, HBeAg-negative hepatitis phase; HBeAg, hepatitis B e antigen; HBsAg, hepatitis B surface antigen;ALT, alanine aminotransferase; AST, aspartate aminotransferase; TBIL, total bilirubin; ALB, albumin.
When the serum viral load of HBV DNA is less than 500 IU/mL, it is recognized as negative.