Table 6. Univariate and multivariate analyses of survival (Cox regression).
| Variables | Survival | |
|---|---|---|
| HR (95% CI) | P value | |
| Univariate analysis | ||
| Sex | 0.614(0.223-1.692) | 0.346 |
| Male/female | ||
| Age (yr) | 1.395(0.408-4.769) | 0.595 |
| ≤60/> 60 | ||
| WHO pathology classification | 0.382(0.110-1.330) | 0.131 |
| Keratinizing | ||
| Nonkeratinizig | ||
| undifferentiated | ||
| T stage | 2.823(0.943-8.447) | 0.064 |
| T1-T2/T3-T4 | ||
| Lymph node metastasis | 0.502(0.168-1.505) | 0.219 |
| N0/N1-3 | ||
| TNM stage | 2.877(1.147-7.213) | 0.024 |
| III/IV | ||
| BRCA1 expression | 3.141(1.041-9.472) | 0.042 |
| Negative/positive | ||
| ERCC1 expression | 6.327(1.457-27.483) | 0.014 |
| Negative/positive | ||
| Correlation between BRCA1 and ERCC1 | ||
| BRCA1 (−) and ERCC1 (−) | Reference group | |
| BRCA1 (+) and ERCC1 (−) | 4.126 (1.268-13.428) | 0.019 |
| BRCA1 (−) and ERCC1 (+) | 4.297 (1.363-13.545) | 0.013 |
| BRCA1 (+) and ERCC1(−) | 4.410 (1.543-12.604) | 0.006 |
| Multivariate analysis | ||
| TNM stage | 2.923(1.155-7.393) | 0.024 |
| III/IV | ||
| BRCA1 expression | 1.743(0.557-5.456) | 0.340 |
| Negative/positive | ||
| ERCC1 expression | 5.582(1.233-25.274) | 0.026 |
| Negative/positive | ||
| Correlation between BRCA1 and ERCC1 | ||
| BRCA1 (−) and ERCC1 (−) | Reference group | |
| BRCA1 (+) and ERCC1 (−) | 3.582 (1.098-11.6.85) | 0.034 |
| BRCA1 (−) and ERCC1 (+) | 4.786 (1.516-15.107) | 0.008 |
| BRCA1 (+) and ERCC1(+) | 5.157 (1.798-14.792) | 0.002 |
HR: Hazard ratio; CI: Confidence interval.