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. 2017 Mar 31;8(19):32027–32042. doi: 10.18632/oncotarget.16757

Figure 1. OL suppresses HFD-stimulated tumor growth and lymph node (LN) metastasis in C57BL/6 mice injected with B16F10 cells.

Figure 1

(A, B) Bioluminescence imaging (BLI) was conducted at 5, 10, and 17 days after B16F10-luc cell injection. (A) Representative images of bioluminescent signals. (B) Quantitative analysis of luciferase signals. (C) The primary tumor was resected 3 weeks after injection of B16F10 cells and weighed. (D, E) After resecting the tumors, bioluminescent signals from the draining LNs were monitored at 10 and 15 days after resection. (D) Representative images of luciferase signals. (E) Quantitative analysis of luciferase signals. (F-H) The LNs were removed 17 days after tumor resection. (F) The incidence of metastasis to LNs. (G) The draining LN weight. (H) The tumor weights in the draining LN. Each bar represents the mean ± SEM (n = 20). *Significantly different from the CD group, P < 0.05. Means without a common letter differ among the three HFD groups, P < 0.05.