Crystal structure of (3S*,4R*)-4-fluoro-3-(4-meth­oxy­phen­yl)-1-oxo-2-phenyl-1,2,3,4-tetra­hydro­iso­quinoline-4-carb­oxy­lic acid

The title compound exhibits a cis conformation with respect to the F atom and the methine H atom. It crystallized from a racemic mixture as a pure diastereomer, hence the unit-cell contains both the 3S,4R- and 3R,4S-enanti­omers.

Abstract

The title compound, C₂₃H₁₈FNO₄, crystallized as a racemate. It exhibits a cis conformation with respect to the F atom and the methine H atom. The piperidine ring has a screw-boat conformation. The meth­oxy­phenyl ring and the phenyl ring are inclined to the mean plane of the iso­quinoline ring system by 89.85 (4) and 46.62 (5)°, respectively, and by 78.15 (5)° to one another. In the crystal, mol­ecules are linked by an O—H⋯O hydrogen bond forming chains propagating along the a-axis direction. The chains are linked by C—H⋯F hydrogen bonds, forming layers lying parallel to the ab plane.

Chemical context  

Several decades ago, Cushman et al. (1977 ▸) described a general synthesis of 4-carb­oxy-3,4-di­hydro­isoquinolin-1(2H)-ones by a condensation reaction of various aldimines with homophthalic anhydride. In most cases, a mixture of trans and cis diastereomers was obtained. As the trans isomer is the thermodynamically more stable product, it was possible to epimerize the cis compound completely to the more stable isoform. Accordingly, Haimova et al. (1977 ▸) reported the isolation of the pure thermodynamic product after the treatment of the reaction mixture with 10% NaOH solution.

Combined synthesis conditions resulted in isolation of stereopure trans compound (±) 3 (Fig. 1 ▸). First of all, the imine derivative 1 was synthesized by condensation of 4-meth­oxy­benzaldehyde and aniline. Conversion of homophthalic anhydride 2 with 1 in conc. HOAc gave a diastereomeric cis/trans mixture, which was completely converted to the pure trans enanti­omers by treatment with 8 M NaOH solution. The cis/trans isomers can be differentiated by the proton-coupling constants J_AB between H-3 and H-4, being J_AB 1.5 Hz for the trans compounds and J_AB 6.0 Hz for the cis isomers.

Figure 1.

Synthesis scheme to obtain the trans-isomer (±) 3. Reagents and conditions: (a) EtOH, r.t., 3 h; (b) homophthalic anhydride (2), conc. HOAc, 393 K, 5 h; EtOH, 8 M NaOH, r.t., 24 h.

To prevent epimerization during subsequent synthesis steps, e.g. an amide formation, the isosteric substitution of the acidic proton H-4 by a fluorine atom was investigated (Fig. 2 ▸). First, the carb­oxy­lic acid (±) 3 was protected by tert-butyl ester to obtain the ester (±) 4 (Takeda et al., 1994 ▸). Fluorination to (±) 5 was achieved by deprotonation with lithiumbis(tri­methyl­sil­yl)amide (LiHMDS) and addition of N-fluoro­benzene­sulfonimide (NFSI) (Differding & Ofner, 1991 ▸; Davis et al., 1995 ▸). Finally, the fluorinated product was deprotected using mild conditions (Li et al., 2006 ▸) to obtain the pure diastereomer (±) 6.

Figure 2.

Synthesis scheme to obtain the fluorinated cis-enanti­omers (±) 6. Reagents and conditions: (a) absolute THF, DMAP, di-tert-butyl dicarbonate, r.t., 24 h; (b) absolute THF, LiHMDS, NFSI, 201 K–r.t., 42 h; (c) CH₃CN, 85% (w/w) H₃PO₄, 323 K, 4 d.

Structural commentary  

Compound (±) 6 exhibits a cis-conformation with respect to the fluorine atom F12 and the H atom H10, as shown in Fig. 3 ▸. The piperidine ring (N1/C2/C3/C8–C10) has a screw-boat conformation [puckering amplitude Q = 0.3812 (11) Å, θ = 64.50 (17)°, φ = 279.15 (18)°]. The meth­oxy­phenyl ring (C16–C21) and the phenyl ring (C24–C29) are inclined to the mean plane of the iso­quinoline ring system (N1/C1–C10) by 89.85 (4) and 46.62 (5)°, respectively, and by 78.15 (5)° to one another.

Figure 3.

The mol­ecular structure of compound (±) 6, with atom labelling and 50% probability displacement ellipsoids.

Supra­molecular features  

In the crystal, mol­ecules are linked by an O—H⋯O hydrogen bond, between the carb­oxy­lic OH group (OH14) and amide oxygen atom (O11), forming chains propagating along the a-axis direction (Fig. 4 ▸ and Table 1 ▸). The chains are linked by C—H⋯F hydrogen bonds, forming layers parallel to the ab plane (Fig. 4 ▸ and Table 1 ▸). Individual chains are homo-chiral, with adjacent molecules related by translation only. It is interesting that carboxylate inversion dimers are not observed. It is supposed that the formation of such dimers is hindered by the quite strong F⋯ H interactions, causing a fixed arrangement between the chain layers.

Figure 4.

A view along the c axis of the crystal packing of compound (±) 6, with hydrogen bonds drawn as dashed lines (see Table 1 ▸). For clarity, only H atoms H14 and H23C (grey balls) have been included.

Table 1. Hydrogen-bond geometry (Å, °).

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
O14—H14⋯O11i	0.84	1.75	2.5645 (11)	163
C23—H23C⋯F12ii	0.98	2.50	3.2435 (14)	133

Symmetry codes: (i) ; (ii) .

Synthesis and crystallization  

The synthesis of the title compound, (±) 6, is outlined in Figs. 1 ▸ and 2 ▸.

1-(4-Meth­oxy­phen­yl)- N -phenyl­methanimine (1): Synthesized according to the procedure reported by Torregrosa et al. (2005 ▸). The imine was prepared by condensation of 4-meth­oxy­benzaldehyde (5.00 g, 36.7 mmol) and aniline (3.40 ml, 36.7 mmol) in EtOH (20 ml) at room temperature to obtain colourless crystals (yield 7.20 g, 34.0 mmol, 92%). The NMR spectra and melting point corresponds to reported data (Torregrosa et al., 2005 ▸).

trans -3-(4-Meth­oxy­phen­yl)-1-oxo-2-phenyl-1,2,3,4-tetra­hydro­iso­quinoline-4-carb­oxy­lic acid, (±) 3: Synthesized according to the procedure reported by Guy et al. (2013 ▸). Homophthalic anhydride (3.50 g, 21.5 mmol) was dissolved in conc. HOAc, 1 (6.00 g, 28.4 mmol) was added and the reaction mixture stirred for 4 h at 393 K. Afterwards, the mixture was adjusted to neutral pH value with NaOH solution and extracted with CHCl₃, the organic phase dried over Na₂SO₄ and concentrated in vacuo. The crude product was purified by silica gel chromatography (CHCl₃/EtOH/FA 10/0.3/0.1) to isolate mixture of cis/trans-diastereomers. The solid was dissolved in EtOH (10 ml), 8 M NaOH solution (2.30 ml) was added and the reaction mixture stirred for 24 h at room temperature. After adjusting the pH value to acidic conditions, the mixture was extracted with CHCl₃, dried over Na₂SO₄ and concentrated in vacuo to obtain a racemic mixture of trans-enanti­omers as a colourless amorphous solid (yield 6.50 g, 17.3 mmol, 77%; m.p. 443–444 K). ¹H NMR (CDCl₃, 400 MHz): δ 8.27–8.22 (m, 1H), 7.49–7.44 (m, 2H), 7.27–7.16 (m, 6H), 7.05–7.01 (m, 2H), 6.75–6.72 (m, 2H), 5.52 (s, 1H), 3.97 (d, J = 1.4 Hz, 1H), 3.72 (s, 3H). ¹³C NMR (CDCl₃, 100 MHz): δ 174.5, 163.7, 159.4, 142.2, 132.7, 132.2, 130.9, 129.6, 129.5, 129.1, 128.8, 128.6, 127.7 (2C), 127.3, 126.9, 114.3 (2C), 64.4, 55.3, 51.6. IR 1723, 1602, 1510, 1491, 1462, 1247, 1172, 1027, 828, 730, 693, 628 cm⁻¹. ESI–MS: m/z 374.2 [M + H⁺].

tert -Butyl- trans -3-(4-meth­oxy­phen­yl)-1-οxo-2-phenyl-1,2,3,4-tetra­hydro­iso­quinoline-4-carboxyl­ate, (±) 4: 2.50 g of 3 (6.70 mmol) were dissolved in abs. THF (70 ml). After the addition of di-tert-butyl­dicarbonate (1.40 ml, 6.00 mmol) and DMAP (81.5 mg, 0.70 mmol) the reaction mixture stirred for 24 h at room temperature. Afterwards the reaction was quenched with water (100 ml), extracted with CHCl₃, dried over Na₂SO₄ and concentrated in vacuo. The crude product was purified by MPLC (petroleum ether/EtOAc 1/0 to 0/1) to isolate 4 as a colourless amorphous solid (yield 1.60 g, 3.70 mmol, 55%; m.p. 421–422 K). ¹H NMR (CDCl₃, 400 MHz): δ 8.25–8.21 (m, 1H), 7.45–7.41 (m, 2H), 7.33–7.32 (m, 4H), 7.24–7.19 (m, 1H), 7.17–7.15 (m, 1H), 7.08–7.05 (m, 2H), 6.75–6.71 (m, 2H), 5.54 (d, J = 1.4 Hz, 1H), 3.89 (d, J = 1.7 Hz, 1H), 3.71 (s, 3H), 1.38 (s, 9H). ¹³C NMR (CDCl₃, 100 MHz): δ 169.9, 163.5, 159.2, 142.6, 133.4, 132.3, 131.6, 129.6, 129.4, 129.0, 128.4, 128.3, 127.7 (2C), 126.9, 126.6, 114.2 (2C), 82.5, 64.7, 55.3, 53.2, 28.0. IR 2975, 1730, 1661, 1510, 1399, 1300, 1244, 1139, 1028, 826 cm⁻¹. ESI–MS: m/z 430.1 [M + H⁺].

tert -Butyl- cis -4-fluoro-3-(4-μeth­oxy­phen­yl)-1-oxo-2-phen­yl-1,2,3,4-tetra­hydro­iso­quinoline-4-carboxyl­ate, (±) 5: 500 mg of compound 4 (1.20 mmol) were dissolved in abs. THF (38 ml) under an argon atmosphere and cooled to 301 K. After the addition of 1 M LiHMDS solution (1.40 ml, 1.40 mmol), the mixture was stirred for 1 h while cooling. Afterwards, NFSI (511 mg, 1.60 mmol) was added and the mixture stirred for a further 30 min at 301 K and then 40 h at room temperature. The reaction mixture was extracted with CHCl₃, dried over Na₂SO₄ and concentrated in vacuo. The crude product was purified by MPLC (petroleum ether/EtOAc 1/0 to 0/1) to isolate (±) 5 as colourless crystals (yield 320 mg, 0.70 mmol, 62%; m.p. 452–453 K). ¹H NMR (CDCl₃, 400 MHz): δ 8.41–8.39 (m, 1H), 7.69–7.60 (m, 2H), 7.51–7.48 (m, 1H), 7.34–7.29 (m, 2H), 7.27–7.23 (m, 1H), 7.11–7.07 (m, 2H), 6.92–6.88 (m, 2H), 6.72–6.68 (m, 2H), 5.21 (d, J = 15.7 Hz, 1H), 3.73 (s, 3H), 1.26 (s, 9H). ¹³C NMR (CDCl₃, 100 MHz): δ 165.8 (d, J _CF = 26.8 Hz), 162.0 (d, J _CF = 1.3 Hz), 160.1, 141.3, 132.6 (d, J _CF = 2.9 Hz), 132.3, 130.9 (d, J _CF = 3.9 Hz), 130.3 (d, J _CF = 3.2 Hz), 130.1 (2C), 129.3, 129.2 (d, J _CF = 2.7 Hz), 128.4 (d, J _CF = 3.5 Hz), 127.8, 127.7, 126.9 (d, J _CF = 8.9 Hz), 114.1 (2C), 92.5 (d, J _CF = 189.9 Hz), 84.4, 70.9 (d, J _CF = 28.3 Hz), 55.3, 27.8. ¹⁹F NMR (CDCl₃, 188 MHz): δ −123.4. IR 2929, 1737, 1664, 1513, 1458, 1416, 1306, 1250, 1156, 1031 cm⁻¹. ESI–MS: m/z 448.1 [M + H⁺].

Synthesis of the title compound: cis -4-fluoro-3-(4-meth­oxy­phen­yl)-1-oxo-2-phenyl-1,2,3,4-tetra­hydro­iso­quinoline-4-carb­oxy­lic acid, (±) 6: 68.5 mg of 5 (0.20 mmol) were dissolved in CH₃CN (1.2 ml), 85% (w/w) H₃PO₄ (86.5 µl, 0.80 mmol) was added and the mixture stirred at 323 K for 4 d. Afterwards, the mixture was extracted with CHCl₃, dried over Na₂SO₄ and concentrated in vacuo. The crude product was purified by MPLC (EtOAc to EtOAc+0.1% FA) to isolate (±) 6 as colourless crystals (yield 21.3 mg, 54.0 mmol, 36%; m.p. 461–462 K). ¹H NMR (DMSO-d ₆, 400 MHz): δ 8.22–8.17 (m, 1H), 7.75–7.70 (m, 2H), 7.59–7.55 (m, 1H), 7.34–7.31 (m, 2H), 7.24–7.20 (m, 1H), 7.13–7.10 (m, 2H), 7.00–6.69 (m, 2H), 6.77–6.74 (m, 2H), 5.53 (d, J = 14.0 Hz, 1H), 3.66 (s, 3H). ¹³C NMR (DMSO-d ₆, 100 MHz): δ 167.6 (d, J _CF = 26.6 Hz), 161.6, 159.2, 140.8, 132.9 (d, J _CF = 1.5 Hz), 132.5 (d, J _CF = 19.3 Hz), 130.7 (d, J _CF = 3.0 Hz), 129.7, 129.2 (d, J _CF = 3.6 Hz), 128.8, 128.3, 127.5, 127.4, 127.0, 125.9 (d, J _CF = 6.6 Hz), 113.7 (2C), 92.6 (d, J _CF = 188.0 Hz), 68.7 (d, J _CF = 28.1 Hz), 55.0. ¹⁹F NMR (CD₃OD, 188 MHz): δ −130.0. IR 2834, 2594, 1737, 1617, 1511, 1464, 1281, 1219, 1036 cm⁻¹. ESI–MS: m/z 392.0 [M + H⁺].

Refinement  

Crystal data, data collection and structure refinement details are summarized in Table 2 ▸. The H atoms were included in calculated positions and treated as riding: O—H = 0.84 Å, C–H = 0.95–1.00 Å with U _iso(H) = 1.5U _eq(O-hydroxyl,C-meth­yl) and 1.2U _eq(C) for other H atoms.

Table 2. Experimental details.

Crystal data
Chemical formula	C23H18FNO4
M r	391.38
Crystal system, space group	Monoclinic, P21/c
Temperature (K)	100
a, b, c (Å)	8.4849 (11), 15.407 (3), 14.157 (2)
β (°)	102.598 (16)
V (Å3)	1806.1 (5)
Z	4
Radiation type	Mo Kα
μ (mm−1)	0.11
Crystal size (mm)	0.28 × 0.20 × 0.18
Data collection
Diffractometer	Bruker D8 Quest
Absorption correction	Multi-scan (SADABS; Bruker, 2014 ▸)
T min, T max	0.718, 0.746
No. of measured, independent and observed [I > 2σ(I)] reflections	48705, 3697, 3509
R int	0.024
(sin θ/λ)max (Å−1)	0.625
Refinement
R[F 2 > 2σ(F 2)], wR(F 2), S	0.032, 0.081, 1.05
No. of reflections	3697
No. of parameters	264
H-atom treatment	H-atom parameters constrained
Δρmax, Δρmin (e Å−3)	0.38, −0.21

Computer programs: APEX2 and SAINT-Plus (Bruker, 2014 ▸), SHELXT (Sheldrick, 2015a ▸), SHELXL2014 (Sheldrick, 2015b ▸), SHELXLE (Hübschle et al., 2011 ▸) and Mercury (Macrae et al., 2008 ▸).

Supplementary Material

CCDC reference: 1535140

Additional supporting information: crystallographic information; 3D view; checkCIF report

supplementary crystallographic information

Crystal data

C23H18FNO4	F(000) = 816
Mr = 391.38	Dx = 1.439 Mg m−3
Monoclinic, P21/c	Mo Kα radiation, λ = 0.71073 Å
a = 8.4849 (11) Å	Cell parameters from 9581 reflections
b = 15.407 (3) Å	θ = 2.8–28.3°
c = 14.157 (2) Å	µ = 0.11 mm−1
β = 102.598 (16)°	T = 100 K
V = 1806.1 (5) Å3	Block, colourless
Z = 4	0.28 × 0.20 × 0.18 mm

Data collection

Bruker D8 Quest diffractometer	3697 independent reflections
Radiation source: microfocus sealed tube (Incoatec ImS)	3509 reflections with I > 2σ(I)
Multi-layer mirror monochromator	Rint = 0.024
Detector resolution: 10.24 pixels mm-1	θmax = 26.4°, θmin = 2.6°
φ and ω scans	h = −10→10
Absorption correction: multi-scan (SADABS; Bruker, 2014)	k = −19→19
Tmin = 0.718, Tmax = 0.746	l = −17→17
48705 measured reflections

Refinement

Refinement on F2	Secondary atom site location: difference Fourier map
Least-squares matrix: full	Hydrogen site location: inferred from neighbouring sites
R[F2 > 2σ(F2)] = 0.032	H-atom parameters constrained
wR(F2) = 0.081	w = 1/[σ2(Fo2) + (0.0355P)2 + 1.0295P] where P = (Fo2 + 2Fc2)/3
S = 1.05	(Δ/σ)max = 0.001
3697 reflections	Δρmax = 0.38 e Å−3
264 parameters	Δρmin = −0.21 e Å−3
0 restraints	Extinction correction: (SHELXL2016; Sheldrick, 2015b), Fc*=kFc[1+0.001xFc2λ3/sin(2θ)]-1/4
Primary atom site location: structure-invariant direct methods	Extinction coefficient: 0.0347 (17)

Special details

Experimental. The crystal was immersed in a film of perfluoropolyether oil, mounted on a polyimide microloop (MicroMounts of MiTeGen) and transferred to stream of cold nitrogen (Bruker Kryoflex2).Melting points were determined on a Melting point meter MPM-H2 (Schorpp Geraetetechnik, Ueberlingen, Germany) and were not corrected. IR spectra were obtained using a JASCO FT/IR-6100 spectrometer (JASCO, Gross-Umstadt, Germany). TLC was performed on pre-coated aluminium sheets with silica gel 60 F254 (Macherey-Nagel, Dueren, Germany). 1H (400 MHz) and 13C (100 MHz) NMR spectra were recorded on a Bruker AV 400 instrument (Bruker Biospin, Ettlingen, Germany). 19F (188 MHz) NMR spectra were recorded on a Bruker Advance 200Hz Spektrometer (Bruker Biospin, Bremen, Germany) at 298 K. Chemical shifts are given in ppm and were calibrated on residual solvent peaks as internal standard (CDCl3: 1H 7.26 ppm, 13C 77.1 ppm; DMSO-d6: 1H 2.50 ppm, 13C 39.52 ppm; CD3OD: 1H 3.31 ppm, 13C 49.00 ppm (Gottlieb et al., 1997)). NMR signals are specified as s (singlet), d (doublet), m (multiplet). Coupling constants J are given in Hz. Medium pressure liquid chromatography (MPLC) was performed on puriFlash®430 system (Interchim, Montluçon, France) using pre-packed silica gel 50 µ columns from Interchim (Montluçon, France). MS data were obtained using an Agilent 1100 Series LC/MSD Trap (Agilent Technologies, Boeblingen, Germany). Commercial available chemicals were used without further purification. Gottlieb, H. E., Kotlyar, V. & Nudelman, A. (1997). J. Org. Chem.62, 7512-7515.

Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Ų)

	x	y	z	Uiso*/Ueq
N1	0.33200 (10)	0.61320 (6)	0.66591 (6)	0.01065 (19)
C2	0.24318 (12)	0.57637 (7)	0.72408 (7)	0.0111 (2)
C3	0.32751 (12)	0.51757 (7)	0.80230 (7)	0.0111 (2)
C4	0.24489 (13)	0.48959 (7)	0.87212 (8)	0.0137 (2)
H4	0.139982	0.511308	0.871797	0.016*
C5	0.31679 (13)	0.42986 (7)	0.94204 (8)	0.0159 (2)
H5	0.262356	0.411839	0.990646	0.019*
C8	0.48373 (12)	0.48743 (7)	0.80421 (7)	0.0110 (2)
C7	0.55226 (13)	0.42559 (7)	0.87261 (8)	0.0146 (2)
H7	0.656607	0.403150	0.872799	0.018*
C6	0.46852 (14)	0.39665 (7)	0.94054 (8)	0.0167 (2)
H6	0.515302	0.353782	0.986387	0.020*
C9	0.56834 (12)	0.51784 (7)	0.72743 (7)	0.0104 (2)
C10	0.50982 (12)	0.60708 (7)	0.68386 (7)	0.0103 (2)
H10	0.538244	0.609658	0.618980	0.012*
O11	0.09652 (9)	0.59098 (5)	0.71148 (6)	0.01599 (18)
F12	0.53273 (7)	0.45825 (4)	0.64999 (4)	0.01453 (16)
C13	0.75401 (12)	0.52245 (7)	0.76088 (8)	0.0113 (2)
O14	0.82294 (9)	0.51358 (6)	0.68636 (6)	0.01713 (18)
H14	0.919081	0.530769	0.701830	0.026*
O15	0.82280 (9)	0.53632 (6)	0.84323 (6)	0.01743 (19)
C16	0.59280 (12)	0.68403 (7)	0.74097 (7)	0.0108 (2)
C17	0.55319 (13)	0.71191 (7)	0.82625 (8)	0.0133 (2)
H17	0.469288	0.683326	0.848858	0.016*
C18	0.63400 (13)	0.78083 (7)	0.87914 (8)	0.0142 (2)
H18	0.606692	0.798420	0.937867	0.017*
C19	0.75537 (12)	0.82394 (7)	0.84538 (8)	0.0125 (2)
C20	0.79674 (13)	0.79631 (7)	0.76033 (8)	0.0139 (2)
H20	0.880507	0.824902	0.737609	0.017*
C21	0.71594 (13)	0.72720 (7)	0.70881 (8)	0.0131 (2)
H21	0.744716	0.708909	0.650739	0.016*
O22	0.83760 (9)	0.89465 (5)	0.88880 (6)	0.01602 (18)
C23	0.81993 (14)	0.91544 (8)	0.98427 (8)	0.0175 (2)
H23A	0.883876	0.967223	1.007349	0.026*
H23B	0.857866	0.866633	1.027671	0.026*
H23C	0.705912	0.926726	0.983278	0.026*
C24	0.25598 (12)	0.67125 (7)	0.58933 (8)	0.0124 (2)
C25	0.16993 (13)	0.74324 (7)	0.60909 (9)	0.0174 (2)
H25	0.160006	0.754905	0.673429	0.021*
C26	0.09829 (14)	0.79821 (8)	0.53368 (10)	0.0239 (3)
H26	0.038507	0.847210	0.546762	0.029*
C27	0.11357 (15)	0.78197 (8)	0.43966 (10)	0.0257 (3)
H27	0.065221	0.819873	0.388597	0.031*
C28	0.19975 (15)	0.71015 (9)	0.42085 (9)	0.0236 (3)
H28	0.210460	0.698898	0.356566	0.028*
C29	0.27096 (13)	0.65417 (8)	0.49529 (8)	0.0167 (2)
H29	0.329296	0.604724	0.481866	0.020*

Atomic displacement parameters (Ų)

	U11	U22	U33	U12	U13	U23
N1	0.0066 (4)	0.0132 (4)	0.0116 (4)	0.0003 (3)	0.0007 (3)	0.0019 (3)
C2	0.0094 (5)	0.0113 (5)	0.0128 (5)	−0.0010 (4)	0.0025 (4)	−0.0019 (4)
C3	0.0101 (5)	0.0109 (5)	0.0119 (5)	−0.0024 (4)	0.0017 (4)	−0.0015 (4)
C4	0.0118 (5)	0.0154 (5)	0.0143 (5)	−0.0033 (4)	0.0039 (4)	−0.0023 (4)
C5	0.0180 (5)	0.0176 (5)	0.0127 (5)	−0.0070 (4)	0.0045 (4)	0.0002 (4)
C8	0.0101 (5)	0.0106 (5)	0.0121 (5)	−0.0027 (4)	0.0019 (4)	−0.0013 (4)
C7	0.0118 (5)	0.0131 (5)	0.0178 (5)	−0.0010 (4)	0.0009 (4)	0.0007 (4)
C6	0.0185 (5)	0.0149 (5)	0.0148 (5)	−0.0033 (4)	−0.0006 (4)	0.0040 (4)
C9	0.0088 (5)	0.0108 (5)	0.0111 (5)	−0.0006 (4)	0.0015 (4)	−0.0023 (4)
C10	0.0071 (5)	0.0133 (5)	0.0110 (5)	0.0001 (4)	0.0028 (4)	0.0014 (4)
O11	0.0079 (4)	0.0188 (4)	0.0215 (4)	0.0009 (3)	0.0038 (3)	0.0035 (3)
F12	0.0135 (3)	0.0146 (3)	0.0154 (3)	−0.0022 (2)	0.0030 (2)	−0.0051 (2)
C13	0.0096 (5)	0.0095 (5)	0.0150 (5)	0.0006 (4)	0.0034 (4)	0.0017 (4)
O14	0.0087 (4)	0.0271 (4)	0.0165 (4)	−0.0028 (3)	0.0047 (3)	−0.0019 (3)
O15	0.0109 (4)	0.0258 (4)	0.0146 (4)	−0.0015 (3)	0.0005 (3)	0.0002 (3)
C16	0.0090 (5)	0.0102 (5)	0.0126 (5)	0.0014 (4)	0.0010 (4)	0.0022 (4)
C17	0.0118 (5)	0.0135 (5)	0.0156 (5)	−0.0010 (4)	0.0052 (4)	0.0015 (4)
C18	0.0152 (5)	0.0144 (5)	0.0137 (5)	0.0004 (4)	0.0048 (4)	−0.0005 (4)
C19	0.0108 (5)	0.0102 (5)	0.0148 (5)	0.0002 (4)	−0.0009 (4)	0.0012 (4)
C20	0.0107 (5)	0.0148 (5)	0.0166 (5)	−0.0015 (4)	0.0040 (4)	0.0032 (4)
C21	0.0126 (5)	0.0148 (5)	0.0125 (5)	0.0008 (4)	0.0039 (4)	0.0016 (4)
O22	0.0173 (4)	0.0146 (4)	0.0162 (4)	−0.0053 (3)	0.0036 (3)	−0.0024 (3)
C23	0.0171 (5)	0.0191 (5)	0.0152 (5)	−0.0036 (4)	0.0015 (4)	−0.0036 (4)
C24	0.0078 (4)	0.0129 (5)	0.0150 (5)	−0.0030 (4)	−0.0009 (4)	0.0031 (4)
C25	0.0122 (5)	0.0151 (5)	0.0230 (6)	−0.0011 (4)	−0.0002 (4)	−0.0002 (4)
C26	0.0144 (5)	0.0142 (6)	0.0383 (7)	−0.0008 (4)	−0.0046 (5)	0.0042 (5)
C27	0.0196 (6)	0.0217 (6)	0.0287 (7)	−0.0075 (5)	−0.0102 (5)	0.0134 (5)
C28	0.0228 (6)	0.0285 (7)	0.0162 (6)	−0.0091 (5)	−0.0026 (5)	0.0069 (5)
C29	0.0152 (5)	0.0183 (6)	0.0157 (5)	−0.0032 (4)	0.0012 (4)	0.0021 (4)

Geometric parameters (Å, º)

N1—C2	1.3560 (14)	C16—C21	1.3960 (15)
N1—C24	1.4444 (13)	C17—C18	1.3907 (15)
N1—C10	1.4774 (12)	C17—H17	0.9500
C2—O11	1.2386 (13)	C18—C19	1.3946 (15)
C2—C3	1.4878 (14)	C18—H18	0.9500
C3—C4	1.3987 (15)	C19—O22	1.3655 (13)
C3—C8	1.3992 (15)	C19—C20	1.3923 (15)
C4—C5	1.3912 (16)	C20—C21	1.3847 (15)
C4—H4	0.9500	C20—H20	0.9500
C5—C6	1.3899 (17)	C21—H21	0.9500
C5—H5	0.9500	O22—C23	1.4282 (13)
C8—C7	1.3920 (15)	C23—H23A	0.9800
C8—C9	1.5023 (14)	C23—H23B	0.9800
C7—C6	1.3880 (16)	C23—H23C	0.9800
C7—H7	0.9500	C24—C25	1.3895 (16)
C6—H6	0.9500	C24—C29	1.3899 (16)
C9—F12	1.4112 (12)	C25—C26	1.3940 (17)
C9—C10	1.5440 (14)	C25—H25	0.9500
C9—C13	1.5445 (14)	C26—C27	1.388 (2)
C10—C16	1.5187 (14)	C26—H26	0.9500
C10—H10	1.0000	C27—C28	1.384 (2)
C13—O15	1.2036 (14)	C27—H27	0.9500
C13—O14	1.3202 (13)	C28—C29	1.3935 (16)
O14—H14	0.8400	C28—H28	0.9500
C16—C17	1.3901 (15)	C29—H29	0.9500
C2—N1—C24	119.90 (8)	C21—C16—C10	119.43 (9)
C2—N1—C10	123.43 (9)	C16—C17—C18	121.29 (10)
C24—N1—C10	116.15 (8)	C16—C17—H17	119.4
O11—C2—N1	120.70 (10)	C18—C17—H17	119.4
O11—C2—C3	121.52 (9)	C17—C18—C19	119.57 (10)
N1—C2—C3	117.78 (9)	C17—C18—H18	120.2
C4—C3—C8	120.18 (10)	C19—C18—H18	120.2
C4—C3—C2	118.68 (9)	O22—C19—C20	115.65 (9)
C8—C3—C2	121.08 (9)	O22—C19—C18	124.66 (10)
C5—C4—C3	119.81 (10)	C20—C19—C18	119.67 (10)
C5—C4—H4	120.1	C21—C20—C19	120.09 (10)
C3—C4—H4	120.1	C21—C20—H20	120.0
C6—C5—C4	119.78 (10)	C19—C20—H20	120.0
C6—C5—H5	120.1	C20—C21—C16	120.96 (10)
C4—C5—H5	120.1	C20—C21—H21	119.5
C7—C8—C3	119.39 (10)	C16—C21—H21	119.5
C7—C8—C9	121.58 (9)	C19—O22—C23	117.14 (8)
C3—C8—C9	118.86 (9)	O22—C23—H23A	109.5
C6—C7—C8	120.17 (10)	O22—C23—H23B	109.5
C6—C7—H7	119.9	H23A—C23—H23B	109.5
C8—C7—H7	119.9	O22—C23—H23C	109.5
C7—C6—C5	120.53 (10)	H23A—C23—H23C	109.5
C7—C6—H6	119.7	H23B—C23—H23C	109.5
C5—C6—H6	119.7	C25—C24—C29	120.38 (10)
F12—C9—C8	107.70 (8)	C25—C24—N1	120.76 (10)
F12—C9—C10	105.86 (8)	C29—C24—N1	118.85 (10)
C8—C9—C10	113.83 (8)	C24—C25—C26	119.43 (11)
F12—C9—C13	107.42 (8)	C24—C25—H25	120.3
C8—C9—C13	114.13 (9)	C26—C25—H25	120.3
C10—C9—C13	107.41 (8)	C27—C26—C25	120.57 (12)
N1—C10—C16	112.29 (8)	C27—C26—H26	119.7
N1—C10—C9	110.66 (8)	C25—C26—H26	119.7
C16—C10—C9	114.28 (8)	C28—C27—C26	119.51 (11)
N1—C10—H10	106.3	C28—C27—H27	120.2
C16—C10—H10	106.3	C26—C27—H27	120.2
C9—C10—H10	106.3	C27—C28—C29	120.63 (12)
O15—C13—O14	125.92 (10)	C27—C28—H28	119.7
O15—C13—C9	123.50 (9)	C29—C28—H28	119.7
O14—C13—C9	110.50 (9)	C24—C29—C28	119.48 (11)
C13—O14—H14	109.5	C24—C29—H29	120.3
C17—C16—C21	118.42 (10)	C28—C29—H29	120.3
C17—C16—C10	122.12 (9)
C24—N1—C2—O11	1.02 (15)	F12—C9—C13—O15	−148.60 (10)
C10—N1—C2—O11	172.43 (10)	C8—C9—C13—O15	−29.28 (14)
C24—N1—C2—C3	−179.57 (9)	C10—C9—C13—O15	97.91 (12)
C10—N1—C2—C3	−8.16 (15)	F12—C9—C13—O14	34.57 (11)
O11—C2—C3—C4	−10.34 (15)	C8—C9—C13—O14	153.90 (9)
N1—C2—C3—C4	170.26 (9)	C10—C9—C13—O14	−78.92 (10)
O11—C2—C3—C8	166.87 (10)	N1—C10—C16—C17	50.04 (13)
N1—C2—C3—C8	−12.53 (15)	C9—C10—C16—C17	−77.06 (12)
C8—C3—C4—C5	−1.71 (16)	N1—C10—C16—C21	−131.70 (10)
C2—C3—C4—C5	175.53 (10)	C9—C10—C16—C21	101.20 (11)
C3—C4—C5—C6	−1.68 (16)	C21—C16—C17—C18	−0.31 (16)
C4—C3—C8—C7	3.75 (15)	C10—C16—C17—C18	177.98 (9)
C2—C3—C8—C7	−173.41 (9)	C16—C17—C18—C19	1.09 (16)
C4—C3—C8—C9	179.22 (9)	C17—C18—C19—O22	176.94 (10)
C2—C3—C8—C9	2.05 (15)	C17—C18—C19—C20	−1.42 (16)
C3—C8—C7—C6	−2.42 (16)	O22—C19—C20—C21	−177.51 (9)
C9—C8—C7—C6	−177.76 (10)	C18—C19—C20—C21	0.99 (16)
C8—C7—C6—C5	−0.97 (17)	C19—C20—C21—C16	−0.21 (16)
C4—C5—C6—C7	3.03 (17)	C17—C16—C21—C20	−0.14 (15)
C7—C8—C9—F12	84.49 (12)	C10—C16—C21—C20	−178.47 (9)
C3—C8—C9—F12	−90.87 (11)	C20—C19—O22—C23	−169.09 (9)
C7—C8—C9—C10	−158.47 (9)	C18—C19—O22—C23	12.49 (15)
C3—C8—C9—C10	26.17 (13)	C2—N1—C24—C25	54.81 (14)
C7—C8—C9—C13	−34.68 (14)	C10—N1—C24—C25	−117.20 (11)
C3—C8—C9—C13	149.96 (9)	C2—N1—C24—C29	−125.51 (11)
C2—N1—C10—C16	−93.63 (11)	C10—N1—C24—C29	62.48 (12)
C24—N1—C10—C16	78.07 (11)	C29—C24—C25—C26	0.14 (16)
C2—N1—C10—C9	35.38 (13)	N1—C24—C25—C26	179.82 (10)
C24—N1—C10—C9	−152.92 (9)	C24—C25—C26—C27	−0.58 (17)
F12—C9—C10—N1	75.45 (10)	C25—C26—C27—C28	0.49 (18)
C8—C9—C10—N1	−42.65 (11)	C26—C27—C28—C29	0.05 (18)
C13—C9—C10—N1	−170.02 (8)	C25—C24—C29—C28	0.38 (16)
F12—C9—C10—C16	−156.62 (8)	N1—C24—C29—C28	−179.30 (10)
C8—C9—C10—C16	85.28 (11)	C27—C28—C29—C24	−0.48 (17)
C13—C9—C10—C16	−42.08 (11)

Hydrogen-bond geometry (Å, º)

D—H···A	D—H	H···A	D···A	D—H···A
O14—H14···O11i	0.84	1.75	2.5645 (11)	163
C23—H23C···F12ii	0.98	2.50	3.2435 (14)	133

Symmetry codes: (i) x+1, y, z; (ii) −x+1, y+1/2, −z+3/2.