Erratum: Simvastatin Attenuates Radiation-Induced Murine Lung Injury and Dysregulated Lung Gene Expression

To the Editor:

We have discovered a problem with one of the figures in our article that was published in the March 2011 issue of the Journal (1). The panel in Figure 3A labeled “RILI 6 wks” (upper row right) and the panel labeled “RILI 8 wks” (middle row left) are in fact different versions of the same image. Because of a problem with the labeling of a previous layout of the lung histology panels, a version of the RILI 6 wks slide was inadvertently used instead of the RILI 8 wks image. Below, we print the corrected version of the figure with the RILI 8 wks panel included.

Figure 3.

Lung histology and nitrotyrosine expression in murine RILI. (A) Hematoxylin and eosin staining of murine lung sections are shown. Compared with control lungs, considerable damage to type I pneumocytes was evident at 4 weeks after irradiation (25 Gy), without visible edema and inflammation. Lungs from mice at 6 weeks after irradiation exhibited modest alveolar flooding and inflammatory foci in scattered areas, with perivascular clustering of inflammatory cells prominent at 8 and 12 weeks. (B) Immunohistochemical localization of nitrotyrosine reveals radiation-induced increases in the lungs of exposed mice. Compared with controls, strong immunoreactivity of nitrotyrosine at 4 weeks after irradiation was observed in the alveolar epithelium (red arrow), pneumocytes, and airway epithelium (blue arrow).

The authors regret the confusion caused by the error.