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Crossing NOD.H2h4 and BALB/c To Generate F1, N2, and F2 Offspring
| Mouse Strains Crossed | Nomenclature |
|---|---|
| BALB/c male × NOD.H2h4 female | F1 |
| F1 male × to NOD.H2h4 female | N2 |
| F1 male × F1 female | F2 |
Some N2 mice were derived from F1 males bearing the human TSHR A-subunit transgene (Lo or Hi expressor) (18, 19) bred to nontransgenic NOD.H2h4 females. All F2 mice were derived from nontransgenic F1 mice.
