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. Author manuscript; available in PMC: 2018 Jan 18.
Published in final edited form as: Chemistry. 2016 Dec 5;23(4):725–751. doi: 10.1002/chem.201603884

Figure 6.

Figure 6

Caged Xe biosensor concept, and Hyper-CEST detection. a) Different Xe hosts confer different chemical shifts to the bound atoms that enable readout at distinct resonance frequencies. b) Xe inside a molecular host changes its resonance frequency upon binding to a target structure. c) Selective Hyper-CEST saturation at one of these frequencies causes a cloud of depolarized Xe around the respective host. The reduced signal from free Xe represents an amplified information from the small amount of cages. d) Sweeping the saturation pulse over a certain frequency range and subsequent observation of the magnetization from free Xe yields a Hyper-CEST spectrum for comparing the performance of different hosts.