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. 2017 Apr 4;8(20):33501–33514. doi: 10.18632/oncotarget.16819

Figure 8. Macrophages/IL-1β/γδT cells/IL-17 axis is involved in IL-35-induced expression of G-CSF in vivo.

Figure 8

(A) ELISA analysis of IL-17A in the serum of naive mice, pUN01-mice and pIL-35-mice. (B) Mice were untreated or treated with anti-IL-17A antibody to neutralize IL-17A in vivo. G-CSF levels in serum of naive mice, pUN01-mice, and pIL-35-mice were detected by ELISA. (C) ELISA analysis of IL-1β in the serum of naive mice, pUN01-mice and pIL-35-mice. (D) After depletion of γδ T cells with anti-γδ TCR antibody in vivo, the levels of G-CSF and IL-17A in serum of naive mice, pUN01-mice, and pIL-35-mice were detected by ELISA. (E) Mice were untreated or treated with anti-IL-1β antibody to neutralize IL-1β in vivo. G-CSF and IL-17A levels in serum of naive mice, pUN01-mice, and pIL-35-mice were detected by ELISA. **p < 0.01.