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. 2017 Apr 4;8(20):33779–33795. doi: 10.18632/oncotarget.16810

Figure 5. Transcriptional profiling of Colo-205 xenografted tumors revealed differences between SEL120-34A and two other CDK8 inhibitors - CCT251545 (CMPD1) and CMPD3.

Figure 5

(A) Venn diagram showing overlap in significantly regulated genes by SEL120-34A 30mg/kg, CCT251545 (CMPD1) 70mg/kg and CMPD3 20mg/kg (Clarke et al.) based on adj. p-values. A list of common genes between SEL120-34A and both CMPD1 and CMPD3 is shown in tabular form. (B) Heatmaps presenting Z-scores for the top list of genes regulated in Colo-205 tumors by the treatment with SEL120-34A, CCT251545 (CMPD1) and CMPD3 (Clarke et al.). Gene names with a blue background indicate presence of STAT binding sites and red indicate HOXA binding sites in the promoters as analyzed by SABiosciences' database DECODE. Tables present GSEA analysis (MSigDB C2 collection) for expression changes in Colo-205 xenografts after treatments with indicated compounds, Enrichment Scores (ES), Normalized Enrichment Scores (NES) and False Discovery Rates (FDR) are shown.