Table 3. Meta-analysis of the associations between 18F-FDG PET parameters and survival outcomes.
| Endpoint | Volumetric parameters | Factor | No. of studies | Heterogeneity test (I2, P) | Effect model | HR | 95%CI of HR | Conclusion |
|---|---|---|---|---|---|---|---|---|
| EFS | SUVmax | Cutoff method | ||||||
| ROC | 8 | 20 | fixed | 1.94 | 1.47-2.58 | significant | ||
| Others | 3 | 50 | random | 10.37 | 2.52-42.69 | significant | ||
| Threshold | ||||||||
| ≥8.78 | 5 | 90 | random | 3.72 | 1.01-13.67 | significant | ||
| <8.78 | 6 | 64 | random | 3.76 | 1.76-8.04 | significant | ||
| Analysis method | ||||||||
| Univariate analysis | 7 | 69 | random | 2.88 | 1.44-5.79 | significant | ||
| Multivariate analysis | 4 | 3 | fixed | 2.42 | 1.62-3.62 | significant | ||
| OS | SUVmax | Cutoff method | ||||||
| ROC | 5 | 0 | fixed | 2.13 | 1.45-3.12 | significant | ||
| Others | 2 | 0 | fixed | 1.98 | 1.23-3.21 | significant | ||
| Threshold | ||||||||
| ≥8.78 | 5 | 0 | fixed | 1.89 | 1.38-2.60 | significant | ||
| <8.78 | 2 | 0 | fixed | 4.47 | 1.78-11.22 | significant | ||
| Analysis method | ||||||||
| Univariate analysis | 5 | 0 | fixed | 1.8 | 1.25-2.59 | significant | ||
| Multivariate analysis | 2 | 0 | fixed | 2.77 | 1.65-4.66 | significant |