Table 2. Summary of meta-analysis results for BMI and bladder cancer risk.
Analysis specification | Studies | SRR (95%CI) | I2 (%) | P* |
---|---|---|---|---|
Overweight | ||||
All | 14 | 1.03 (0.95-1.11) | 30.4 | 0.133 |
Mean age | ||||
≥50 | 5 | 1.01 (0.43-1.21) | 24.8 | 0.104 |
<50 | 7 | 0.94 (0.87-1.34) | 0.0 | 0.419 |
Year of publication | ||||
≥2008 | 6 | 1.03 (0.89-1.09) | 3.4 | 0.411 |
<2008 | 8 | 1.05 (0.78-1.28) | 0.0 | 0.633 |
Follow-up duration | ||||
≥10 years | 8 | 0.96 (0.57-1.23) | 0.0 | 0.857 |
<10 years | 6 | 1.07 (0.89-1.18) | 16.2 | 0.153 |
Sample size | ||||
≥1,000,000 | 4 | 1.05 (0.45-1.37) | 0.0 | 0.477 |
<1,000,000 | 10 | 1.01 (0.96-1.10) | 54.6 | 0.031 |
Assessment of BMI | ||||
Measured | 6 | 1.10 (0.91-1.23) | 53.4 | 0.008 |
Self-reported | 7 | 1.02 (1.86-1.15) | 12.9 | 0.301 |
Geographic area | ||||
Asia | 3 | 1.02 (0.97-1.08) | 0 | 0.675 |
Europe | 4 | 1.06 (0.97-1.73) | 47.0 | 0.100 |
America | 4 | 1.03 (0.79-1.34) | 0.0 | 0.861 |
Multi–international centers | 2 | 1.09 (0.98-1.56) | 12.9 | 0.351 |
Physical activity | ||||
Yes | 2 | 1.07 (0.94-1.29) | 35.9 | 0.191 |
No | 12 | 1.15 (1.00-1.98) | 42.7 | 0.121 |
Family history of cancer | ||||
Yes | 2 | 1.15(0.93–1.29) | 12.8 | 0.543 |
No | 12 | 1.06(1.00–1.19) | 36.1 | 0.087 |
Obesity | ||||
All | 14 | 1.10 (1.03-1.17) | 58.5 | 0.003 |
Mean age | ||||
≥50 | 6 | 1.19 (1.08-1.22) | 19.9 | 0.267 |
<50 | 6 | 1.01 (1.09-1.68) | 56.8 | 0.061 |
Year of publication | ||||
≥2008 | 6 | 1.10 (1.53-1.89) | 27.1 | 0.171 |
<2008 | 8 | 1.02 (1.14-1.40) | 66.2 | 0.000 |
Follow-up duration | ||||
≥10 years | 8 | 1.30 (1.02-1.39) | 0.0 | 0.424 |
<10 years | 6 | 1.07 (1.04-1.74) | 10.3 | 0.231 |
Sample size | ||||
≥1,000,000 | 4 | 1.14 (1.01-1.61) | 24.8 | 0.200 |
<1,000,000 | 10 | 1.04 (1.08-1.54) | 37.1 | 0.112 |
Assessment of BMI | ||||
Measured | 7 | 1.09(1.02–1.13) | 12.5 | 0.354 |
Self-reported | 6 | 1.24(1.09–1.40) | 32.4 | 0.187 |
Geographic area | ||||
Europe | 3 | 1.84 (1.55-2.19) | 0.0 | 0.651 |
America | 4 | 1.97 (1.40-2.75) | 18.8 | 0.214 |
Asia | 3 | 2.29 (1.46-3.58) | 17.1 | 0.341 |
Smoking | ||||
Yes | 2 | 1.11(1.05–2.16) | 24.1 | 0.145 |
No | 12 | 1.17(1.05–1.46) | 8.81 | 0.653 |
Family history of cancer | ||||
Yes | 2 | 1.13(1.07–1.19) | 29.9 | 0.201 |
No | 12 | 1.09(1.04–1.13) | 1.83 | 0.412 |
BMI: Body mass index, SRR: The summary relative risk, *P value for heterogeneity.