FIG. 2.

Gene expression of TR isoforms in mouse liver after T3 treatment and its withdrawal. Adult male mice (8–10 weeks old) were treated with 20 μg of LT3/100 g body weight for 14 days followed by cessation of LT3 for 10 days. Relative mRNA expression of liver Thrb (A) and Thra (B) were determined at indicated T3 treatment periods after the first LT3 injections. No treatment (blank); acute T3 treatment (black); chronic T3 treatment (hashed); T3 withdrawal (striped) are shown. Data are presented as means ± standard error of the mean (SEM; n = 4–5/group). *p < 0.05; **p < 0.01 determined by one-way analysis of variance (ANOVA) compared to no treatment (0 days).