Abstract
A wild-type strain of Micrococcus radiodurans and its nonpigmented mutant W1 were tested for sensitivity to 10 antibiotics selected from the standpoint of their mechanism of action. Representatives of groups of antibiotics inhibiting deoxyribonucleic acid (DNA) synthesis, DNA-dependent ribonucleic acid synthesis, protein synthesis, and cell wall synthesis were selected. M. radiodurans and its mutant exhibited full susceptibility to all antibiotics tested (mitomycin C, actinomycin D, chloramphenicol, dihydrostreptomycin, erythromycin, neomycin, kanamycin, benzylpenicillin, bacitracin, and vancomycin), the degree of susceptibility being of the same order as that of a standard strain of Staphylococcus aureus 209 P, with the exception of dihydrostreptomycin.
Full text
PDF


Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BOYCE R. P., HOWARD-FLANDERS P. GENETIC CONTROL OF DNA BREAKDOWN AND REPAIR IN E. COLI K-12 TREATED WITH MITOMYCIN C OR ULTRAVIOLET LIGHT. Z Vererbungsl. 1964 Dec 30;95:345–350. doi: 10.1007/BF01268667. [DOI] [PubMed] [Google Scholar]
- BROCK T. D. ACTION OF STREPTOMYCIN AND RELATED ANTIBIOTICS. Fed Proc. 1964 Sep-Oct;23:965–975. [PubMed] [Google Scholar]
- BRUCE A. K. EXTRACTION OF THE RADIORESISTANT FACTOR OF MICROCOCCUS RADIODURANS. Radiat Res. 1964 May;22:155–164. [PubMed] [Google Scholar]
- GALE E. F., FOLKES J. P. The assimilation of amino-acids by bacteria. XIV. Nucleic acid and protein synthesis in Staphylococcus aureus. Biochem J. 1953 Feb;53(3):483–492. doi: 10.1042/bj0530483. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GOLDBERG I. H., REICH E. ACTINOMYCIN INHIBITION OF RNA SYNTHESIS DIRECTED BY DNA. Fed Proc. 1964 Sep-Oct;23:958–964. [PubMed] [Google Scholar]
- GOUREVITCH A., PURSIANO T. A., LEIN J. Destruction of mitomycin by Streptomyces casepitosus mycelia. Arch Biochem Biophys. 1961 May;93:283–285. doi: 10.1016/0003-9861(61)90263-6. [DOI] [PubMed] [Google Scholar]
- GREENBERG J., WOODY-KARRER P. RADIOSENSITIVITY IN ESCHERICHIA COLI. J Gen Microbiol. 1963 Nov;33:283–292. doi: 10.1099/00221287-33-2-283. [DOI] [PubMed] [Google Scholar]
- KERSTEN W. Interaction of actinomycin C with constituents of nucleic acids. Biochim Biophys Acta. 1961 Mar 4;47:610–611. doi: 10.1016/0006-3002(61)90564-9. [DOI] [PubMed] [Google Scholar]
- MOSELEY B. E., LASER H. REPAIR OF X-RAY IN MICROCOCCUS RADIODURANS. Proc R Soc Lond B Biol Sci. 1965 Apr 13;162:210–222. doi: 10.1098/rspb.1965.0035. [DOI] [PubMed] [Google Scholar]
- MOSELEY B. E., SCHEIN A. H. RADIATION RESISTANCE AND DEOXYRIBONUCLEIC ACID BASE COMPOSITION OF MICROCOCCUS RADIODURANS. Nature. 1964 Sep 19;203:1298–1299. doi: 10.1038/2031298a0. [DOI] [PubMed] [Google Scholar]
- NATHANS D., LIPMANN F. Amino acid transfer from aminoacyl-ribonucleic acids to protein on ribosomes of Escherichia coli. Proc Natl Acad Sci U S A. 1961 Apr 15;47:497–504. doi: 10.1073/pnas.47.4.497. [DOI] [PMC free article] [PubMed] [Google Scholar]
- NIRENBERG M. W., MATTHAEI J. H. The dependence of cell-free protein synthesis in E. coli upon naturally occurring or synthetic polyribonucleotides. Proc Natl Acad Sci U S A. 1961 Oct 15;47:1588–1602. doi: 10.1073/pnas.47.10.1588. [DOI] [PMC free article] [PubMed] [Google Scholar]
- RENDI R., OCHOA S. Effect of chloramphenicol on protein synthesis in cell-free preparations of Escherichia coli. J Biol Chem. 1962 Dec;237:3711–3713. [PubMed] [Google Scholar]
- SCHWARTZ H. S., PHILIPS F. S. Pharmacology of mitomycin C. II. Renal excretion and metabolism by tissue hemogenates. J Pharmacol Exp Ther. 1961 Sep;133:335–342. [PubMed] [Google Scholar]
- SCHWARTZ H. S. Pharmacology of mitomycin C. III. In vitro metabolism by rat liver. J Pharmacol Exp Ther. 1962 May;136:250–258. [PubMed] [Google Scholar]
- SETLOW J. K., DUGGAN D. E. THE RESISTANCE OF MICROCOCCUS RADIODURANS TO ULTRAVIOLET RADIATION. I. ULTRAVIOLET-INDUCED LESIONS IN THE CELL'S DNA. Biochim Biophys Acta. 1964 Aug 12;87:664–668. doi: 10.1016/0926-6550(64)90284-1. [DOI] [PubMed] [Google Scholar]
- SZYBALSKI W., IYER V. N. CROSSLINKING OF DNA BY ENZYMATICALLY OR CHEMICALLY ACTIVATED MITOMYCINS AND PORFIROMYCINS, BIFUNCTIONALLY "ALKYLATING" ANTIBIOTICS. Fed Proc. 1964 Sep-Oct;23:946–957. [PubMed] [Google Scholar]
- WORK E. AMINO ACIDS OF WALLS OF MICROCOCCUS RADIODURANS. Nature. 1964 Mar 14;201:1107–1109. doi: 10.1038/2011107a0. [DOI] [PubMed] [Google Scholar]