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. 1967 Mar;15(2):344–349. doi: 10.1128/am.15.2.344-349.1967

Kinetics of the Thermal Inactivation of Type E Clostridium botulinum Toxin1

J J Licciardello 1, C A Ribich 1, J T R Nickerson 1, S A Goldblith 1
PMCID: PMC546903  PMID: 5339840

Abstract

Rate of inactivation curves for the “free” toxin, prototoxin, or activated toxin in crude filtrates of Clostridium botulinum type E were nonlinear, consisting of a fast inactivating rate followed by a slow inactivating rate. Thermodynamic parameters were calculated over a temperature range of 125 to 145 F (51.7 to 62.8 C) for the two different inactivation rates. Energy of activation was low at the lower temperature and high at the higher temperature. The thermal requirement for inactivating similar concentrations of the “free” toxin, prototoxin, or activated toxin was considered to be the same.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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