Table 2.
Univariable Logistic Regression Analysis for Predicting Early Postoperative Atrial Fibrillation After LAA Closure
| Covariates | Unmatched Cohort | Propensity-Matched Cohort | ||
|---|---|---|---|---|
| OR (95% CI) | P Value | OR (95% CI) | P Value | |
| Demographics | ||||
| Age | 1.05 (1.04–1.05) | <0.001 | 1.05 (1.03–1.06) | <0.001 |
| Female, sex | 1.01 (0.92–1.10) | 0.91 | 1.23 (0.94–1.60) | 0.14 |
| BMI | 1.00 (0.99, 1.01) | 0.77 | 1.01 (0.98–1.03) | 0.69 |
| Creatinine | 1.08 (1.01–1.16) | 0.03 | 1.10 (0.85–1.39) | 0.50 |
| LVEF | 0.99 (0.99–1.00) | 0.01 | 0.99 (0.98–1.00) | 0.20 |
| History variables | ||||
| Hypertension | 1.26 (1.15–1.37) | <0.001 | 1.39 (1.07–1.81) | 0.02 |
| Diabetes mellitus | 0.96 (0.87–1.07) | 0.47 | 0.99 (0.69–1.42) | 0.94 |
| Dyslipidemia | 1.02 (0.93–1.12) | 0.73 | 1.04 (0.80–1.35) | 0.77 |
| History of AF | 1.71 (1.53–1.91) | <0.001 | 2.38 (1.82–3.11) | <0.001 |
| Prior stroke | 1.24 (1.04–1.46) | 0.01 | 1.74 (1.02–2.95) | 0.04 |
| Previous MI | 1.09 (0.99–1.20) | 0.09 | 1.21 (0.81–1.81) | 0.35 |
| Congestive heart failure | 1.40 (1.25–1.55) | <0.001 | 1.20 (0.90–1.61) | 0.21 |
| Smoker | 1.01 (0.93–1.10) | 0.85 | 1.16 (0.89–1.50) | 0.28 |
| Peripheral arterial disease | 0.98 (0.87–1.11) | 0.76 | 1.18 (0.69–2.00) | 0.55 |
| Chronic lung disease | 1.22 (1.09–1.38) | 0.001 | 1.20 (0.82–1.75) | 0.34 |
| Prior surgery | 0.77 (0.69–0.87) | <0.001 | 0.90 (0.55–1.46) | 0.66 |
| Preoperative medications | ||||
| β-Blocker | 1.09 (1.00–1.19) | 0.05 | 1.33 (1.03–1.73) | 0.03 |
| Antiarrhythmics | 0.93 (0.77–1.11) | 0.42 | 0.58 (0.36–0.93) | 0.02 |
| Calcium channel blocker | 1.16 (1.05–1.28) | 0.003 | 1.52 (1.09–2.13) | 0.01 |
| Statin | 1.16 (1.06–1.26) | 0.001 | 1.08 (0.84–1.41) | 0.54 |
| ACE-I or ARB | 0.98 (0.90–1.06) | 0.57 | 1.16 (0.87–1.54) | 0.31 |
| Digoxin | 1.32 (1.15–1.51) | <0.001 | 1.24 (0.91–1.69} | 0.18 |
| Surgical data | ||||
| LAA closure | 4.62 (3.79–5.64) | <0.001 | 3.37 (2.57–4.42) | <0.001 |
| Isolated CABG | 0.78 (0.71–0.85) | <0.001 | 2.89 (1.18–4.20) | 0.01 |
| Aortic valve surgery | 1.22 (1.11–1.34) | <0.001 | 1.16 (0.77–1.75) | 0.48 |
| Mitral valve surgery | 1.55 (1.39–1.74) | <0.001 | 0.84 (0.64–1.10) | 0.20 |
| Tricuspid valve surgery | 0.75 (0.52–1.06) | 0.10 | 1.11 (0.48–2.57) | 0.80 |
| Pulmonary valve surgery | 0.56 (0.12–2.71) | 0.47 | – | – |
| Combined CABG+valve or other | 0.79 (0.70–0.88) | <0.001 | 0.95 (0.69–1.31) | 0.76 |
| Perfusion time, min | 1.002 (1.001–1.003) | <0.001 | 1.001 (0.998–1.005) | 0.38 |
ACE-I indicates angiotensin-converting enzyme inhibitor; AF, atrial fibrillation; ARB, angiotensin receptor blocker; CABG, coronary artery bypass grafting; CI, confidence interval; LAA, left atrial appendage; LVEF, left ventricular ejection fraction; MI, myocardial infarction; and OR, odds ratio.