Skip to main content
Applied Microbiology logoLink to Applied Microbiology
. 1967 May;15(3):531–532. doi: 10.1128/am.15.3.531-532.1967

Broad-Spectrum Antimicrobial Activity of a New Triazenoimidazole

Robert F Pittillo 1, Dale E Hunt 1
PMCID: PMC546961  PMID: 4962284

Abstract

Methyl-5(or 4)-(3,3-dimethyl-1-triazeno)-imidazole-4(or 5)-carboxylate was shown to have in vitro antimicrobial activity against gram-positive and gram-negative bacteria, yeasts, filamentous fungi, and algae. Preliminary studies with mice, experimentally infected with Staphylococcus aureus, have shown that this new antimicrobial agent has in vivo chemotherapeutic activity comparable to that observed with penicillin.

Full text

PDF
531

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Hunt D. E., Pittillo R. F. Antifungal action of 1,3-bis(2-chloroethyl)-1-nitrosourea. Antimicrob Agents Chemother (Bethesda) 1965;5:710–716. [PubMed] [Google Scholar]
  2. SHEALY Y. F., MONTGOMERY J. A., LASTER W. R., Jr Antitumor activity of triazenoimidazoles. Biochem Pharmacol. 1962 Jul;11:674–676. doi: 10.1016/0006-2952(62)90130-2. [DOI] [PubMed] [Google Scholar]
  3. Shealy J. F., Krauth C. A., Pittillo R. F., Hunt D. E. A new antifungal and antibacterial agent, methyl 5(or 4)-(3,3-dimethyl-1-triazeno)imidazole-4(or 5)-carboxylate. J Pharm Sci. 1967 Jan;56(1):147–148. doi: 10.1002/jps.2600560133. [DOI] [PubMed] [Google Scholar]
  4. Shealy Y. F., Krauth C. A. Complete inhibition of mouse leukaemia L1210 by 5(or 4)-[3,3-bis(2-chloroethyl)-1-triazeno]imidazole-4(or 5)-carboxamide (NSC-82196). Nature. 1966 Apr 9;210(5032):208–209. doi: 10.1038/210208a0. [DOI] [PubMed] [Google Scholar]

Articles from Applied Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES