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. 1967 May;15(3):657–660. doi: 10.1128/am.15.3.657-660.1967

Production of High-Titer Antibody in Serum and Ascitic Fluid of Hamsters for a Variety of Virus-induced Tumor Antigens

Raymond V Gilden 1,2, Theodore G Beddow 1,2, Robert J Huebner 1,2
PMCID: PMC546999  PMID: 4291958

Abstract

Methods not involving the use of viable tumors were developed for production of high-titer antibodies. The methods involved use of tumor homogenates. Homogenates from all tumor lines tested contained the characteristic tumor antigen. Attempts to isolate virus failed, and virus antigens could not be demonstrated. Immunization with tumor homogenates, in Freund's complete adjuvant, resulted in high antibody levels. None of the animals so immunized developed tumors.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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