Abstract
Kasugamycin is an aminoglycosidic antibiotic which was initially reported as being of potential use against Pseudomonas. Our evaluation of this antibiotic does not confirm this expectation. The median minimal inhibitory concentration (MIC) of the Pseudomonas strains tested was 250 μg/ml and the bactericidal level was 500 μg/ml. Kasugamycin was found to be slightly more active in a more basic medium (Mycin Assay broth) in which the median MIC for 11 Pseudomonas strains was 125 μg/ml. Kasugamycin manifests a modest degree of serum binding. Kasugamycin did not have any appreciable effect against a variety of bacteria tested. The only exceptions were several species of gram-negative bacteria, against which more satisfactory antibiotics already exist. Further evaluation of kasugamycin for potential human use as an antipseudomonal agent does not appear warranted.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- HALL J. W., 3rd, ORTH E., Jr Actinospectacin: an in vitro study of effectiveness against pathogenic bacteria. Am J Med Sci. 1962 Jul;244:30–39. doi: 10.1097/00000441-196207000-00004. [DOI] [PubMed] [Google Scholar]
- HAMADA M., HASHIMOTO T., TAKAHASHI T., YOKOYAMA S., MIYAKE M., TAKEUCHI T., OKAMI Y., UMEZAWA H. ANTIMICROBIAL ACTIVITY OF KASUGAMYCIN. J Antibiot (Tokyo) 1965 Mar;18:104–106. [PubMed] [Google Scholar]
- Ichikawa T. Kasugamycin treatment of Pseudomonas infection of the urinary tract. Antimicrob Agents Chemother (Bethesda) 1965;5:758–764. [PubMed] [Google Scholar]
- JACKSON G. G., FINLAND M. Comparison of methods for determining sensitivity of bacteria to antibiotics in vitro. AMA Arch Intern Med. 1951 Oct;88(4):446–460. doi: 10.1001/archinte.1951.03810100030003. [DOI] [PubMed] [Google Scholar]
- Suhara Y., Maeda K., Umezawa H. Chemical studies on kasugamycin. V. The structure of kasugamycin. Tetrahedron Lett. 1966 Mar;12:1239–1244. doi: 10.1016/s0040-4039(01)99701-1. [DOI] [PubMed] [Google Scholar]
- TAKEUCHI T., ISHIZUKA M., TAKAYAMA H., KUREHA K., HAMADA M., UMEZAWA H. PHARMACOLOGY OF KASUGAMYCIN AND THE EFFECT ON PSEUDOMONAS INFECTION. J Antibiot (Tokyo) 1965 Mar;18:107–110. [PubMed] [Google Scholar]
- UMEZAWA H., OKAMI Y., HASHIMOTO T., SUHARA Y., HAMADA M., TAKEUCHI T. A NEW ANTIBIOTIC, KASUGSMYCIN. J Antibiot (Tokyo) 1965 Mar;18:101–103. [PubMed] [Google Scholar]