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. 2017 Mar 27;8(21):34552–34564. doi: 10.18632/oncotarget.16602

Table 2. Upstream factors involved in protein expression responses to KPT-185, AZD-2014, or KPT-185+AZD-2014in MCL cells.

Upstream Regulator Activation z-score P-value Target molecules in dataset
KPT-185
 Upregulated
RICTOR 3.606 5.88E-18 PSME3, RPL10, RPL10A, RPL23, RPL26, RPL28, RPL4, RPL6, RPL7A, RPS10, RPS2, RPS23, RPS3
TP53 1.432 8.79E-03 HMGB2, HSPA8, KPNA2, PSME3, VIM, XPO1
 Downregulated
MYC −3.719 9.94E-12 EEF2, LGALS1, RPL10, RPL19, RPL23, RPL26, RPL27, RPL35, RPL5, RPL6, RPL7A, RPS23, VIM, XPO1
MYCN −3.499 2.88E-26 EEF2, LGALS1, RPL10, RPL19, RPL23, RPL26, RPL27, RPL28, RPL35, RPL4, RPL5, RPL6, RPS2, RPS23, RPS3, RPS4X, VIM
HRAS −1.982 6.54E-03 HSPA8, RPS10, RPS3, VIM
AZD-2014
 Downregulated
HSF1 −1.387 1.17E-06 CCT2, DNAJA1, HSP90AB1, HSPA8, HSPH1
KPT-185+AZD-2014
 Upregulated
TNF 2.795 2.54E-03 FASN, HMGB1, HSP90AB1, HSPA8, HSPD1, PARP1, RRM1, RRM2, TPT1, VIM
INSR 2.224 1.10E-07 ACAA2, ATP5A1, CFL1, FASN, HSPD1, MDH2, PDCD4, RRM1, RRM2
TP53 2.109 2.67E-07 ACAA2, ADH5, FASN, HMGB1, HMGB2, HSP90AB1, HSPA8, HSPD1, KPNA2, MDH2, PSME3, RRM1, RRM2, VIM, XPO1
PTEN 1.724 5.33E-05 ACAA2, FASN, G3BP1, PARP1, PDCD4, PGK1, RRM1
IFNG 1.387 2.38E-02 EEF1A1, FASN, HMGB1, HSP90AB1, HSPA8, HSPD1, PSME3
OSM 1.342 6.73E-03 ADH5, FASN, KRT9, PDCD4, PGK1
Downregulated
p70S6k −1.982 1.03E-09 EEF1A1, EEF2, FASN, PDCD4, VIM
E2F1 −1.673 1.21E-11 CCT2, CSDE1, HMGB1, HMGB2, HNRNPD, HSPA8, HSPD1, HSPE1, KRT1, NCL, RRM1, RRM2, VIM
EGF −1.627 1.10E-04 EEF1A1, FASN, NCL, PDCD4, RRM1, RRM2, VIM
HSF1 −1.458 2.45E-10 CCT2, DNAJA1, FASN, HMGB1, HSP90AB1, HSPA8, HSPD1, HSPE1, PGK1
MYCN −1.387 7.63E-15 EEF1A1, EEF1G, EEF2, EIF4A1, HSP90AB1, HSPD1, NCL, RPL4, RPL6, RPS3A, RPS7, TPI1, VIM

Data were analyzed by Ingenuity Pathway Analysis (IPA) based on the proteins whose expression was consistently altered after indicated treatment in Jeko-1, Z138, JVM2, and MINO cells (Supplementary Table 1).